Side Effects of Anturane (sulfinpyrazone)

Anturane (sulfinpyrazone) is an auricosuric agent used to treat gout. Gout is caused by elevated blood levels of uric acid (hyperuricemia). 

Anturane works by increasing the excretion of uric acid in the urine thereby lowering the elevated levels of uric acid in the blood that are responsible for gout. The brand name Anturane is discontinued in the U.S.

Side effects of Anturane are uncommon and usually mild, including: 

• stomach upset.

Combining the drug with food, milk, or antacids is advised. 

Serious side effects of Anturane include:

• kidney pain,
• uric acid kidney stones, and
• severe anemias (rare).

There are no listed drug interactions of Anturane. Tell your doctor all medications and supplements you use. 

Anturane should be used with caution in pregnant women, weighing the potential risks against the possible benefits. Consult your doctor before breastfeeding. 

Side effects of sulfinpyrazone are uncommon and usually mild. The most frequent adverse reaction is stomach upset.

Accordingly, is advised to combine the drug with:

• food,
• milk or
• antacids.

Sulfinpyrazone, however, can cause kidney pain and uric acid kidney stones. Rarely, it has caused severe anemias.

The most frequently reported adverse reactions with Anturane (sulfinpyrazone) have been upper gastrointestinal disturbances.

In these patients it is advisable to administer the drug with food, milk, or antacids. Despite this precaution, Anturane (sulfinpyrazone) may aggravate or reactivate peptic ulcer.

Rash has been reported. In most instances, this reaction did not necessitate discontinuance of therapy. In general, Anturane (sulfinpyrazone) has not been observed to affect electrolyte balance.

Side effects that have rarely been reported include:

• blood dyscrasias (anemia, leukopenia, agranulocytosis, thrombocytopenia, and aplastic anemia).

There has also been a published report associating Anturane (sulfinpyrazone) , administered concomitantly with other drugs including colchicine, with leukemia following long term treatment of patients with gout. However, the circumstances involved in the two cases reported are such that a cause-and-effect relationship to Anturane (sulfinpyrazone) has not been clearly established.

No information provided.