Generic Name: fentanyl
Brand Name: Duragesic
Drug Class: Opioid Analgesics
What is the fentanyl transdermal patch, and what is it used for?
The prescription fentanyl patch is indicated for the management of pain in opioid-tolerant patients, severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate. The fentanyl transdermal system is used for patients with severe chronic pain, for example, cancer pain.
Patients considered opioid-tolerant are those who are taking, for one week or longer, at least 60 mg of morphine daily, or at least 30 mg of oral oxycodone daily, or at least 8 mg of oral hydromorphone daily, or an equianalgesic dose of another opioid.
What are the side effects of fentanyl transdermal system?
Physical dependence occurs commonly during therapy with opiate agonists such as fentanyl. Abruptly stopping the drug in patients can precipitate a withdrawal reaction.
Symptoms of withdrawal include:
Fentanyl can cause respiratory depression (decreased rate or depth of breathing), muscle rigidity, and slow heart rate. Nausea or vomiting, constipation, and itching can occur during treatment with fentanyl. Transdermal fentanyl can cause a variety of skin reactions. Commonly, redness occurs at the site of application and can last for 6 hours following removal of the patch.
Other side effects include:
- Dry mouth
- Abdominal pain
- Loss of appetite
- Drowsiness
- Confusion
- Headache
- Dizziness
- Nervousness
- Hallucinations
- Anxiety
- Depression
- Euphoria
Possible serious side effects include:
- Hallucinations
- Anxiety
- Depression
- Respiratory depression
- Death (overdose)
- Cardiac arrest
- Fainting
- Severe low blood pressure
- Seizures
- Slow heart rate
- Paralytic ileus
- Abuse
- Withdrawal symptoms
The FDA is investigating reports of deaths and other serious side effects from the use of the fentanyl transdermal system as well as overdoses.
Exposing the patch to heat can increase the amount of fentanyl released and may lead to an overdose. Some patches may cause burns of the skin if worn during an MRI (magnetic resonance imaging) scan. Patients should tell their health-care professional that they are using a medication patch prior to receiving an MRI scan.
Is fentanyl transdermal patch addictive?
- Because of the risks of addiction, abuse, and misuse with opioids, even at recommended doses, and because of the greater risks of overdose and death with extended-release opioid formulations, reserve fentanyl for use in patients for whom alternative treatment options (e.g., non-opioid analgesics or immediate-release opioids) are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain.ride
SLIDESHOW
Rheumatoid Arthritis Exercises: Joint-Friendly Workouts See SlideshowWhat is the dosage for fentanyl transdermal system?
- Patches should be applied to a flat, non-irritated area on the upper torso.
- The area of application should be clean and washed with water only prior to application.
- The patch should be applied immediately after removing it from the package and pressed firmly against the skin for 10 to 20 seconds especially around the edges.
- Patches should never be cut or otherwise damaged.
- Doses required to control pain vary widely among patients.
- The recommended dose is 25 to 100 mcg/hour patch applied every 72 hours.
- The manufacturer considers a fentanyl transdermal dose of 100 µg/hour approximately equivalent to 360 mg/day of oral morphine.
Which drugs interact with fentanyl transdermal system?
The use of fentanyl with other central nervous system depressants can increase the ability of fentanyl to depress breathing, depress the brain, sedate, and lower blood pressure.
Other drugs that may result in slow heart rates in patients when used with fentanyl, and therefore, should be used cautiously include:
- Antipsychotics, for example, Thorazine and Stelazine, haloperidol (Haldol)
- Anxiolytics, for example, diazepam (Valium), lorazepam (Ativan), and zolpidem (Ambien)
- Certain antihistamines, for example, diphenhydramine (Benadryl), and hydroxyzine (Vistaril)
- Barbiturates, for example, phenobarbital (Donnatal)
- Tricyclic antidepressants, for example, amitriptyline (Elavil, Endep) and doxepin (Sinequan), ethanol
- Skeletal muscle relaxants, for example, carisoprodol (Soma), cyclobenzaprine (Flexeril), and baclofen (Lioresal). The use of fentanyl with amiodarone (Cordarone) may result in slow heart rates.
Cimetidine (Tagamet) when used with fentanyl can cause confusion, disorientation, or seizures due to impairment in breathing and brain function.
Pregnancy and breastfeeding
- The fentanyl transdermal system is not recommended for use during pregnancy; it may cause fetal harm.
- Fentanyl from the patch passes into breast milk and may cause undesirable side effects in a nursing infant. Breastfeeding is not recommended while using it.
What else should I know about the fentanyl patch?
What preparations of fentanyl transdermal system are available?
- Transdermal systems labeled as delivering 12, 25, 50, 37.5, 62.5, 75, 87.5, or 100 mcg/hour.
How should I keep fentanyl transdermal system stored?
- Patches should be stored at room temperature below 30 C (86 F). Used patches should be folded in half with the sticky sides together, and then flushed down the toilet.
- Patients must avoid exposing the patches to excessive heat as this promotes the release of fentanyl from the patch and increases the absorption of fentanyl through the skin which can result in fatal overdose.
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Summary
Fentanyl transdermal patch is a synthetic narcotic prescribed for severe pain in patients, for example, with cancer pain. Side effects may include yawning, nasal discharge, twitching muscles, nausea, diarrhea, and coughing. Because fentanyl is an opioid, it carries the risks of addiction, abuse, and misuse. Do not take fentanyl if pregnant or breastfeeding.
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Treatment & Diagnosis
Medications & Supplements
- fentanyl - transdermal, Duragesic
- Drugs: Questions to Ask Your Doctor or Pharmacist about Your Drugs
- Drug Interactions
- What Drugs Are Used for Conscious Sedation?
- Oxycodone for Pain (OxyContin, Roxicodone, Oxecta, Oxaydo, Xtampza ER, Roxybond)
- Percocet
- codeine (for Pain)
- Side Effects of Oxycontin (oxycodone)
- oxycodone/acetaminophen
- fentanyl injection
- OxyContin (oxycodone)
- Side Effects of Percocet (oxycodone/acetaminophen)
- Codeine Side Effects, Warnings, and Interactions
- fentanyl tablet - buccal, Fentora
- fentanyl lozenge - buccal, Actiq
- What Are Opioid Equivalents and Conversions?
- Side Effects of Duragesic (fentanyl patch)
- Percodan (aspirin and oxycodone hydrochloride)
- Subsys (fentanyl)
- Onsolis (fentanyl buccal)
- Fentora (fentanyl citrate)
- Olinvyk (oliceridine)
- Side Effects of Sublimaze (fentanyl)
- Lazanda (fentanyl) nasal spray
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.