What are NSAIDs, and what are they used for?
Prostaglandins are a family of chemicals that are produced by the cells of the body and have several important functions. They promote inflammation that is necessary for healing, but also results in pain, and fever; support the blood clotting function of platelets; and protect the lining of the stomach from the damaging effects of acid.
Prostaglandins are produced within the body's cells by the enzyme cyclooxygenase (COX). There are two COX enzymes, COX-1 and COX-2. Both enzymes produce prostaglandins that promote inflammation, pain, and fever. However, only COX-1 produces prostaglandins that support platelets and protect the stomach.
Nonsteroidal anti-inflammatory drugs (NSAIDs) block the COX enzymes and reduce prostaglandins throughout the body. As a consequence, ongoing inflammation, pain, and fever are reduced. Since the prostaglandins that protect the stomach and support platelets and blood clotting also are reduced, NSAIDs can cause ulcers in the stomach and promote bleeding.
NSAIDs are used primarily to treat inflammation, mild to moderate pain, and fever.
Specific uses include the treatment of:
- headaches,
- arthritis,
- ankylosing spondylitis,
- sports injuries, and
- menstrual cramps.
NSAID examples
- Ketorolac (Toradol) is only used for short-term treatment of moderately severe acute pain that otherwise would be treated with narcotics.
- Aspirin (also an NSAID) is used to inhibit the clotting of blood and prevent strokes and heart attacks in individuals at high risk for strokes and heart attacks.
- NSAIDs also are included in many cold and allergy preparations.
- Celecoxib (Celebrex) is used for treating familial adenomatous polyposis (FAP) to prevent the formation and growth of colon polyps.
NSAID warnings
- Some individuals are allergic to NSAIDs and may develop shortness of breath when an NSAID is taken. People with asthma are at a higher risk for experiencing serious allergic reaction to NSAIDs. Individuals with a serious allergy to one NSAID are likely to experience a similar reaction to a different NSAID.
- Use of aspirin in children and teenagers with chickenpox or influenza has been associated with the development of Reye's syndrome, a serious and sometimes fatal liver disease. Therefore, aspirin and non-aspirin salicylates (for example, salsalate [Amigesic]) should not be used in children and teenagers with suspected or confirmed chickenpox or influenza.
- NSAIDs increase the risk of potentially fatal, stomach and intestinal adverse reactions (for example, bleeding, ulcers, and perforation of the stomach or intestines). These events can occur at any time during treatment and without warning symptoms. Elderly patients are at greater risk for these adverse events.
- NSAIDs (except low dose aspirin) may increase the risk of potentially fatal heart attacks, stroke, and related conditions. This risk may increase with duration of use and in patients who have underlying risk factors for heart and blood vessel disease. Therefore, NSAIDs should not be used for the treatment of pain resulting from coronary artery bypass graft (CABG) surgery.
What NSAIDs are FDA approved in the United States?
The following list is an example of NSAIDs available:
- aspirin
- celecoxib (Celebrex)
- diclofenac (Cambia, Cataflam, Voltaren-XR, Zipsor, Zorvolex)
- diflunisal (Dolobid - discontinued brand)
- etodolac (Lodine - discontinued brand)
- ibuprofen (Motrin, Advil)
- indomethacin (Indocin)
- ketoprofen (Active-Ketoprofen [Orudis - discontinued brand])
- ketorolac (Toradol - discontinued brand)
- nabumetone (Relafen - discontinued brand)
- naproxen (Aleve, Anaprox, Naprelan, Naprosyn)
- oxaprozin (Daypro)
- piroxicam (Feldene)
- salsalate (Disalsate [Amigesic - discontinued brand])
- sulindac (Clinoril - discontinued brand)
- tolmetin (Tolectin - discontinued brand)
SLIDESHOW
Rheumatoid Arthritis Exercises: Joint-Friendly Workouts See SlideshowWhat are the side effects of NSAIDs?
NSAIDs are associated with several side effects. The frequency of side effects varies among NSAIDs.
Common side effects are
- nausea,
- vomiting,
- diarrhea,
- constipation,
- decreased appetite,
- rash,
- dizziness,
- headache, and
- drowsiness.
Other important side effects are:
- kidney failure (primarily with chronic use),
- liver failure,
- ulcers, and
- prolonged bleeding after injury or surgery.
NSAIDs can cause fluid retention, which can lead to edema, which is most commonly manifested by swelling of the ankles.
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What are the differences among NSAIDs?
NSAIDs vary in their potency, duration of action, how they are eliminated from the body, how strongly they inhibit COX-1 versus COX-2 and their tendency to cause ulcers and promote bleeding. The more an NSAID blocks COX-1, the greater is its tendency to cause ulcers and promote bleeding.
- One NSAID, celecoxib (Celebrex), blocks COX-2 but has little effect on COX-1, and is therefore further classified as a selective COX-2 inhibitor. Selective COX-2 inhibitors cause less bleeding and fewer ulcers than other NSAIDs.
- Aspirin is a unique NSAID, not only because of its many uses, but because it is the only NSAID that inhibits the clotting of blood for a prolonged period of time (4 to 7 days). This prolonged effect of aspirin makes it an ideal drug for preventing blood clots that cause heart attacks and strokes.
- Most NSAIDs inhibit the clotting of blood for only a few hours. Ketorolac (Toradol) is a very potent NSAID and is used for moderately severe acute pain that usually requires narcotics. Ketorolac causes ulcers more frequently than other NSAID. Therefore, it is not used for more than five days.
Although NSAIDs have a similar mechanism of action, individuals who do not respond to one NSAID may respond to another.
What drugs do NSAIDs interact with?
- Diuretics: NSAIDs reduce blood flow to the kidneys and therefore reduce the action of diuretics ("water pills") and decrease the elimination of lithium (Eskalith, Lithobid) and methotrexate (Rheumatrex, Trexall). As a result, the blood levels of these drugs may increase as may their side effects.
- Blood thinners: NSAIDs also decrease the ability of the blood to clot and therefore increase bleeding. When used with other drugs that also increase bleeding (for example, warfarin), there is an increased likelihood of serious bleeding or complications of bleeding. Therefore, individuals who are taking drugs that reduce the ability of blood to clot should avoid prolonged use of NSAIDs.
- Blood pressure medications: NSAIDs also may increase blood pressure in patients with hypertension (high blood pressure) and therefore antagonize the action of drugs that are used to treat hypertension.
- Cyclosporine: NSAIDs increase the negative effect of cyclosporine on kidney function.
- Alcohol: Persons who have more than three alcoholic beverages per day may be at increased risk of developing stomach ulcers when taking NSAIDs.
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Summary
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of drugs are used to treat inflammation, mild to moderate pain, and fever. Examples of the most common NSAIDs include: aspirin salsalate (Amigesic), diflunisal (Dolobid), ibuprofen (Motrin), ketoprofen (Orudis), nabumetone (Relafen), piroxicam (Feldene), naproxen (Aleve, Naprosyn,) diclofenac (Voltaren), indomethacin (Indocin), sulindac (Clinoril), tolmetin (Tolectin), etodolac (Lodine), ketorolac (Toradol), oxaprozin (Daypro), celecoxib (Celebrex).
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MiscarriageMiscarriage is the medical term for the spontaneous loss of pregnancy from conception to 20 weeks gestation. Risk factors for a woman having a miscarriage include cigarette smoking, older maternal age, radiation exposure, previous miscarriage, maternal weight, illicit drug use, use of NSAIDs, and trauma or anatomical abnormalities to the uterus. There are five classified types of miscarriage: 1) threatened abortion; 2) incomplete abortion; 3) complete abortion; 4) missed abortion; and (5 septic abortion. While there are no specific treatments to stop a miscarriage, a woman's doctor may advise avoiding certain activities, bed rest, etc. If a woman believes she has had a miscarriage, she needs to seek prompt medical attention.
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Osteoarthritis vs. Osteoporosis Differences and SimilaritiesArthritis is defined as painful inflammation and joint stiffness. Osteoarthritis is a type of arthritis and the most common cause of chronic joint pain, affecting over 25 million Americans. Osteoarthritis is a type of arthritis that involves the entire joint. Osteoporosis is not a type of arthritis. It is a disease that mainly is caused by a loss of bone tissue that is not limited to the joint areas. It is possible for one person to have both osteoarthritis and osteoporosis. The differences in the signs and symptoms of osteoarthritis and osteoporosis include; pain, stiffness, and joint swelling, joint deformity, crackle sounds when the joint is moving, and walking with a limp. Osteoporosis is called the "silent disease" because it can progress for years without signs and symptoms before it is diagnosed, severe back pain, bone fractures, height loss, and difficulty or inability to walk. The differences in the causes of osteoarthritis and osteoporosis are that osteoarthritis usually is caused by wear and tear on the joints. Osteoporosis usually is caused by one or more underlying problems, for example, calcium and vitamin D deficiencies. Treatment for osteoarthritis and osteoporosis are not the same. There is no cure for osteoarthritis or osteoporosis.
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Multiple Sclerosis (MS) Symptoms and TreatmentsMultiple sclerosis (MS) symptoms vary from person to person and can last for days to months without periods of remission. Symptoms of MS include sexual problems and problems with the bowel, bladder, eyes, muscles, speech, swallowing, brain, and nervous system. The early symptoms and signs of multiple sclerosis usually start between ages 20-40. MS in children, teens, and those over age 40 is rare. Treatment options for multiple sclerosis vary depending on the type and severity of symptoms. Medications may be prescribed to manage MS symptoms.
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Knee PainAcute injuries, medical conditions, and chronic use conditions are causes of knee pain. Symptoms that accompany knee pain include redness, swelling, difficulty walking, and locking of the knee. To diagnose knee pain, a physician will perform a physical exam and also may order X-rays, arthrocentesis, blood tests, or a CT scan or MRI.
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What Is the Best Infusion for Rheumatoid Arthritis (RA)?Learn the four most effective DMARDs for rheumatoid arthritis infusion therapy, which aim to control RA symptoms, reduce complications, and improve quality of life and lifespan.
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Cold, Flu, Allergy TreatmentsBefore treating a cold, the flu, or allergies with over-the-counter (OTC) medications, it's important to know what's causing the symptoms, which symptoms one wishes to relieve, and the active ingredients in the OTC product. Taking products that only contain the medications needed for relieving your symptoms prevents ingestion of unnecessary medications and reduces the chances of side effects.
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Menstrual CrampsMenstrual cramps (pain in the belly and pelvic area) are experienced by women as a result of menses. Menstrual cramps are not the same as premenstrual syndrome (PMS). Menstrual cramps are common, and may be accompanied by headache, nausea, vomiting, constipation, or diarrhea. Severity of menstrual cramp pain varies from woman to woman. Treatment includes OTC or prescription pain relief medication.
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Ankylosing SpondylitisAnkylosing spondylitis (AS) is a form of chronic inflammation of the spine and the sacroiliac joints. The tendency to develop ankylosing spondylitis is genetically inherited. Treatment incorporates medications, physical therapy, and exercise.
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Barrett's EsophagusBarrett's esophagus occurs as a complication of chronic gastroesophageal reflux disease (GERD), primarily in white males. GERD refers to the reflux of acidic fluid from the stomach into the esophagus (the swallowing tube) and is classically associated with heartburn. Learn the symptoms, causes, and treatments for Barrett's esophagus.
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PseudogoutPseudogout, a form of arthritis, results when deposits of crystals collect in and around the joints. Pseudogout has many similarities to true gout, which also can cause arthritis.
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Neck PainNeck pain (cervical pain, cervicalgia) may be caused by any number of disorders and diseases. Treatment for neck pain depends upon the cause. Treatment typically involves heat/ice application, traction, physical therapy, cortisone injection, topical anesthetic creams, and muscle relaxants.
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Ankle Pain (Tendonitis)Ankle pain is commonly due to a sprain or tendonitis. The severity of ankle sprains ranges from mild (which can resolve within 24 hours) to severe (which can require surgical repair). Tendonitis of the ankle can be caused by trauma or inflammation.
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Rheumatoid Arthritis vs. ArthritisArthritis is a general term used to describe joint disease. Rheumatoid arthritis (RA) is a type of arthritis in which the body’s immune system mistakenly attacks the joints, causing chronic inflammation.
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Degenerative Disc DiseaseDegenerative disc disease occurs when the rubbery discs (between bones) in the spine wear down. Degenerative disc disease makes the disc more susceptible to herniation (rupture) which can lead to localized or radiating pain. The pain from degenerative disc or joint disease of the spine is usually treated conservatively to relieve pain, muscle spasm, and inflammation.
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Orthostatic HypotensionOrthostatic hypotension is a type of low blood pressure in which a person becomes dizzy, lightheaded, or faints when moving from a sitting position to a standing position. There are a variety of causes of this condition such as dehydration, medications, and diseases and conditions. Treatment depends on the cause of the condition.
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Occipital Neuralgia (Headache)Occipital neuralgia is a type of headache that involves inflammation or irritation of occipital nerves. Signs and symptoms include a stabbing and throbbing head pain, and an aching pain in the upper back of the head and neck. Potential causes include infection, irritation, or trauma of the occipital nerves. This type of headache is diagnosed by physical examination findings and imaging tests. Treatment involves a multidisciplinary approach that includes massage, rest, physical therapy, heat, muscle relaxants, and anti-inflammatory drugs. Invasive procedures and even surgery may be considered if first-line treatments fail to bring relief from the chronic pain of this type of headache.
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Elbow PainElbow pain is most often the result of tendinitis, which can affect the inner or outer elbow. Inflammation, redness, warmth, swelling, tenderness, and decreased range of motion are symptoms associated with elbow pain. Treatment for elbow pain depends upon the nature of the patient's underlying disease or condition.
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Knee Injury and Meniscus TearsKnee injuries, especially meniscus tears, are common in contact sports. Symptoms of a meniscus tear include knee pain, swelling, a popping sound, and difficulty bending the leg. Treatment may involve wearing a knee brace, taking anti-inflammatory medications, and stretching the knee.
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Is It Normal to Have Headaches in Second Trimester Pregnancy?Many women experience headaches during pregnancy. Headaches tend to be worse during the first trimester and they get better in the second and third trimesters although some women still experience headaches during the second trimester.
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Psoriatic ArthritisPsoriatic arthritis is a disease that causes skin and joint inflammation. Symptoms of psoriatic arthritis include painful, stiff, and swollen joints, tendinitis, and organ inflammation. Treatment involves anti-inflammatory medications and exercise.
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Eye AllergyEye allergy (or allergic eye disease) are typically associated with hay fever and atopic dermatitis. Medications and cosmetics may cause eye allergies. Allergic eye conditions include allergic conjunctivitis, conjunctivitis with atopic dermatitis, vernal keratoconjunctivitis, and giant papillary conjunctivitis. Dry eye, tear-duct obstruction, and conjunctivitis due to infection are frequently confused with eye allergies. Eye allergies may be treated with topical antihistamines, decongestants, topical mast-cell stabilizers, topical anti-inflammatory drugs, systemic medications, and allergy shots.
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Prostatitis vs. BPH (Enlarged Prostate): What Is the Difference?Prostatitis and BPH (benign prostatic hyperplasia, enlarged prostate gland) are both conditions of the prostate gland. Check out the center below for more medical references on prostate gland conditions, including multimedia (slideshows, images, and quizzes), related disease conditions, treatment and diagnosis, medications, and prevention or wellness.
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Does Hand Grip Help With Arthritis?Because your hands are engaged in multiple functions every day, hand strength is a powerful predictor of your overall capacity to function and how severe your arthritis is.
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Fungal ArthritisFungal arthritis is inflammation of a joint by a fungus that has invaded the body and is growing in the normally sterile joint. Fungal arthritis symptoms and signs include pain, redness, loss of range of motion, and swelling. Fungal arthritis treatment includes antibiotics, adequate drainage of the joint, and sometimes surgery.
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Piriformis SyndromePiriformis syndrome may develop if the piriformis muscle spasms and compresses the sciatic nerve. This causes buttock pain that radiates down the back of the leg along the sciatic nerve. Symptoms include numbness, a pins-and-needles tingling sensation, and low back pain.
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Fibrocystic BreastsFibrocystic breast disease is characterized by pain, tenderness, and/or discomfort in one or both breasts, often caused by changes in hormones (menstruation, menopause). Learn about causes and treatment.
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Can Rheumatoid Arthritis Affect Your Ability to Walk? 9 LimitationsRheumatoid arthritis can impair your walking ability and result in the following nine types of functional limitations.
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Is Aspirin an Anti-Inflammatory?Aspirin is an anti-inflammatory drug that falls under a drug class called nonsteroidal anti-inflammatory drugs (NSAIDs). Aspirin is used to relieve pain and reduce inflammation and fever. In low doses, it can also be used as a preventative measure against heart attack and stroke.
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Polymyalgia RheumaticaPolymyalgia rheumatica (PMR) is a disorder of the muscles and joints that causes pain and stiffness in the arms, neck, shoulders, and buttocks. Treatment for polymyalgia rheumatica aims to reduce inflammation with aspirin, ibuprofen, and low doses of cortisone medications.
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Sinus HeadacheSinus headache is caused by a sinus infection or inflammation of the sinus cavities. Symptoms of a sinus headache include pain, runny or stuffy nose, and chronic cough. There are many causes of sinus headaches including sinusitis or sinus infection, allergies, smoke, infections, or colds. Treatment for sinus headaches depends on the cause. Some home remedies may relieve sinus headache pain symptoms.
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PericarditisPericarditis is a heart condition in which the pericardium (the sac around your heart) is inflamed. The inflammation may produce a collection of fluid in the pericardial sac called pericardial effusion. Learn the symptoms, causes, diagnosis, and treatments for pericarditis.
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Bone CancerBone cancer is a rare type of cancer that occurs in cells that make up the bones. Primary bone cancer that arises in bone cells is different than metastatic bone cancer, which is cancer that arises in another part of the body and then spreads to the bones. Hereditary and environmental factors likely contribute to the risk of bone cancer. Signs and symptoms of bone cancer may include pain, the presence of a mass or lump, and bone fractures. There are different types of bone cancer (osteosarcoma, chondrosarcoma, Ewing's sarcoma, pleomorphic sarcoma, fibrosarcoma). Treatment for bone cancer may include surgical removal of the tumor, chemotherapy, radiation, and/or a stem cell transplant. The prognosis for bone cancer depends on the type of cancer and the extent of spread.
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Nonsteroidal Anti-inflammatory Drugs and UlcersNonsteroidal anti-inflammatory drugs (NSAIDs) are prescribed medications for the treatment of inflammatory conditions. Examples of NSAIDs include aspirin, ibuprofen, naproxen, and more. One common side effect of NSAIDs is peptic ulcer (ulcers of the esophagus, stomach, or duodenum). Side effects, drug interactions, warnings and precautions, and patient safety information should be reviewed prior to taking NSAIDs.
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Heat ExhaustionHeat exhaustion is a milder form of heat-related illness that can develop after several days of exposure to high temperatures and inadequate or unbalanced replacement fluids. Heat exhaustion can progress to heat stroke (a medical emergency) if not treated.
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Can Rheumatoid Arthritis Be Caused by Stress?Rheumatoid arthritis can be caused by and result in stress, as well as other conditions such as gastrointestinal problems (IBD).
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Tension HeadacheA tension headache is one of the most common types of headaches, and the exact cause is not known. Factors that may contribute to tension or stress headaches are lack of sleep, increased stress (referred to as a stress headache), skipping meals, dehydration, medical diseases or conditions, anxiety, or changes at home, work, or school. Treatment of tension headaches include prescription and OTC medications, stress management, and treating any underlying illness or condition.
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Reactive ArthritisReactive arthritis is a chronic, systemic rheumatic disease characterized by three conditions, including conjunctivitis, joint inflammation, and genital, urinary, or gastrointestinal system inflammation. Inflammation leads to pain, swelling, warmth, redness, and stiffness of the affected joints. Non-joint areas may experience irritation and pain. Treatment for reactive arthritis depends on which area of the body is affected. Joint inflammation is treated with anti-inflammatory medications.
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Migraine vs. Headache: Differences and SimilaritiesHeadaches are the most common reason why a person goes to the doctor or other healthcare professional for treatment. There are different types of headaches, for example, migraine, tension, and cluster headaches. The most common type of headache is tension headache. Migraine is much less common. There are few similarities between migraine and other headaches, for example, the severity of the pain can be the same, mild, moderate, or severe; and they can occur on one side or both sides of the head. However, there are many differences between migraine and other types of headaches. Migraine headaches also have different names, for example, migraine with aura and menstrual migraine. Symptoms of migraine that usually aren't experienced by a person with another type of headache include nausea, vomiting, worsens with mild exercise, debilitating pain, eye pain, throbbing head pain. Migraine trigger include light, mild exercise, strong smells, certain foods like red wine, aged cheese, smoked meats, artificial sweeteners, chocolate, alcohol, and dairy products, menstrual period, stress, oversleeping, and changes in barometric pressure. Untreated migraine attacks usually last from 4 to 72 hours, but may last for weeks. Most headaches resolve within 24-48 hours. Doctors don't know exactly what causes migraine headaches; however, other headaches like tension headaches have more specific triggers and causes. Additional tests usually are required to diagnose migraine from other types of headaches, diseases, or other medical problems. Most headaches can be treated and cured with home remedies like essential oils, massage, and over-the-counter pain medication like acetaminophen (Tylenol) and NSAIDs (nonsteroidal anti-inflammatory drugs) like naproxen (Aleve, Anaprox, Naprosyn) or ibuprofen (Advil, Midol, Motrin). Most headaches resolve with OTC and home remedy treatment, while your doctor may need to prescribe medication to treat your migraines. If you have the "worst headache of your life," seek medical care immediately.
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Cluster HeadachesCluster headaches are a type of headache that recurs over a period. Episodes can last one to three times a day during this time, which may last from 2 weeks to 3 months. The three main types of treatments for cluster headaches are, 1) Abortive medications that work to stop the process in the brain that causes migraines and stops the symptoms too. 2) Preventive prescription medications or 3) surgery that involves blocking the trigeminal nerve.
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ScleritisScleritis is inflammation of the white part of the eye. It may be caused by a serious underlying condition, such as an autoimmune disease. Symptoms include redness, pain, tearing, sensitivity to light, and decreased visual acuity. Treatment may include eyedrops as well as treatment for any underlying disease process. Scleritis cannot be prevented.
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Microscopic ColitisMicroscopic colitis (lymphocytic colitis and collagenous colitis) is a disease of inflammation of the colon. Microscopic colitis is only visible when the colon's lining is examined under a microscope. The cause of microscopic colitis is not known. Symptoms of microscopic colitis are chronic watery diarrhea and abdominal pain or cramps.
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What Are the Causes of a Headache Behind the Eyes?A headache behind the eyes is an uncomfortable sensation that is felt around or on the back of the eye, which may or may not be a throbbing ache. Causes of headaches behind the eyes include tension headaches, migraines, cluster headaches, sinus headaches, occipital neuralgia, brain aneurysm, Grave's disease, scleritis, dry eyes, vision problems, eye strain and poor posture.
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Shin SplintsShin splints are injuries to the front of the outer leg caused by overuse and typically happen to runners or aggressive walkers. Shin splint pain can be extreme enough to prevent you from working out. Rest is usually the best treatment for shin splints, and you can also ice the injury and take over-the-counter (OTC) pain medicine to relieve pain.
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Muscle PainMuscle pain (myalgia, myofascial pain syndrome) is pain in the body's soft tissues due to injury or strain. Symptoms include muscle pain with tender points and fatigue. Treatment usually involves physical therapy, massage therapy, or trigger point injection.
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Septic ArthritisSeptic arthritis, or infectious arthritis, is infection of one or more joints by bacteria, viruses, or fungi. Symptoms and signs of septic arthritis include fever, joint pain, chills, swelling, redness, warmth, and stiffness. Treatment involves antibiotics and the drainage of the infected joint.
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How Long Does Headache Last After Thunderclap?Thunderclap headache is an extremely painful headache that begins suddenly and peaks with intensity within seconds. These headaches can last for at least 5 minutes.
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Knee BursitisBursitis of the knee results when any of the three fluid-filled sacs (bursae) become inflamed due to injury or strain. Symptoms and signs include pain, swelling, warmth, tenderness, and redness. Treatment of knee bursitis depends on whether infection is involved. If the knee bursa is not infected, knee bursitis may be treated with ice compresses, rest, and anti-inflammatory and pain medications.
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Shoulder BursitisShoulder bursitis is inflammation of the shoulder bursa. Bursitis may be caused by injury, infection, or a rheumatic condition. Symptoms include pain, swelling, tenderness, and pain with movement of the shoulder joint. Treatment may involve ice compresses, rest, and anti-inflammatory medications and depends on whether there is an infection.
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First Aid: Why You Need a First Aid Kit and CPRFirst aid is providing medical assistance to someone a sick or injured person. The type of first aid depends on their condition. Preparedness is key to first aid, like having basic medical emergency kits in your home, car, boat, or RV. Many minor injuries may require first aid, including cuts, puncture wounds, sprains, strains, and nosebleeds. Examples of more critical first aid emergencies include heart attacks, strokes, seizures, and heatstroke.
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Rheumatoid Arthritis vs. Ankylosing SpondylitisLearn the differences between rheumatoid arthritis and ankylosing spondylitis below.
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Rheumatoid Arthritis vs. Lupus: Differences and SimilaritiesRheumatoid arthritis (RA) and lupus are two varieties of autoimmune diseases that cause flare-ups. While RA attacks the immune system on the joints, lupus involves many other parts of the body besides the joints. Common RA symptoms involve warm, swollen, and painful joints; morning stiffness in the joints or stiffness after inactivity, joint deformity, fever, fatigue, etc. Lupus symptoms include Malar rash (butterfly-shaped rash involving the cheeks and bridge of the nose), fever, joint pain in the absence of joint deformity, etc.
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Tennis ElbowTennis elbow is also known as lateral epicondylitis. Symptoms of tennis elbow include tenderness and dull pain of the outer elbow. Resting, applying cold packs, and taking anti-inflammatory medications are usually effective treatments for tennis elbow.
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Eosinophilic EsophagitisEosinophilic esophagitis is an inflammation of the esophagus. Eosinophilic esophagitis has many causes including acid reflux, heartburn, viruses, medications that become stuck in the esophagus, allergy, asthma, hay fever, allergic rhinitis, and atopic dermatitis. Eosinophilic esophagitis symptoms include difficulty swallowing food, abdominal pain, chest pain, and heartburn.
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Migraines and SeizuresMigraines are a type of headache and seizures are the main symptom of epilepsy. Migraine headaches and seizures are two different neurological problems that have similar signs, symptoms, and auras, for example, sensitivity to light (photophobia) and sound, irritability, nausea, and vomiting. Symptoms unique to migraine and migraine auras are water retention, problems sleeping, appetite changes, and talkativeness. Symptoms unique to seizure and seizures auras are depression, a feeling of heaviness, a feeling that a seizure is approaching, and depression. Many of the symptoms of migraine and seizures are the same, however, seizures do not cause migraines; however, people who have seizures are twice as likely to have migraines and vice-versa. People who have migraines are twice as likely to have seizures, and people with seizures are twice as likely to have migraines; however, one condition does not cause the other.
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What Happens When You Get Shingles When Pregnant?Becoming infected with chickenpox during pregnancy could cause birth defects in your unborn child. Likewise, shingles could also cause problems for your unborn child. If you are pregnant and haven't had chickenpox, avoid exposure to infected people. Zostavax, the shingles vaccine, can reduce the incidence of shingles by half. Women should wait at least three months after receiving the vaccine before trying to get pregnant.
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How Can You Live With Arthritis in Your Back?Arthritis in the back can be extremely painful and in some cases debilitating. However, effective ways to manage and live with the condition.
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Migraine and StrokeMigraine is a type of headache that causes severe pain on one side of the head. A stroke is a condition that occurs when a blood vessel in the brain is blocked (ischemic), leaks, or bursts (hemorrhagic). In addition to severe head pain, migraine can mimic and have the same symptoms of a stroke.
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Hyperthermia (Heat-Related Illness)There are many types of hyperthermia that range from inconvenient, like heat rash, to life-threatening, like heat stroke. Heat-related illnesses associated with activity like work or exercise include heat cramps, heat syncope, heat exhaustion, and heat stroke.
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Paget's DiseasePaget's disease of bone is a chronic bone disorder due to irregular breakdown and formation of bone tissue. Paget's disease symptoms include bone pain, headaches and hearing loss, pressure on nerves, increased head size, hip pain, and damage to cartilage of joints.
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Breastfeeding With Rheumatoid ArthritisYou can breastfeed your baby even if you have rheumatoid arthritis (RA). However, you must always consult your doctor before you start the process.
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SAPHO SyndromeSAPHO syndrome is a chronic disorder that involves the skin, bone, and joints. SAPHO syndrome is an eponym for the combination of synovitis, acne, pustulosis, hyperostosis, and osteitis. SAPHO syndrome is related to arthritic conditions such as ankylosing spondylitis and reactive arthritis. Treatment is directed toward the individual symptoms that are present.
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Rheumatoid Arthritis vs. Polymyalgia RheumaticaPolymyalgia rheumatica and rheumatoid arthritis are two diseases that manifest in a similar manner.
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Still's DiseaseStill's disease is a disorder characterized by inflammation with high fever spikes, fatigue, salmon-colored rash, and/or arthritis.
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Laryngitis Home RemediesLaryngitis is an inflammation of the larynx. Inflammation of the larynx is most often caused by viral infections. Symptoms include sore throat, cough, problems swallowing, and fever. The voice changes produced by laryngitis may last after the fever and other symptoms of the acute infection have gone away. The best natural home remedy to relieve pain and other symptoms caused by laryngitis includes resting your voice and breathing humidified air often. Turning on the hot water in the bathroom and then sitting in the steam can soothe and relieve laryngitis symptoms. Acetaminophen (Tylenol) and anti-inflammatory drugs (NSAIDs) like ibuprofen (Advil, Aleve) can relieve pain and inflammation caused by laryngitis. Don't give children aspirin to infants, toddlers, children, and teens because of the risk of developing Reye's syndrome, which can be fatal. Home remedies like resting your voice and sitting in humidified air can cure laryngitis. Medications like anti-inflammatory drugs (NSAIDs) like ibuprofen (Advil, Aleve) and acetaminophen (Tylenol) can relieve and soothe pain and symptoms caused by laryngitis.
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Flatfoot (Pes Planus)Flatfoot is a disorder in which the foot's entire sole is touching the ground while standing. Symptoms of flatfoot include heel, ankle, knee, hip, lower back pain, and shin splints. Treatment depends upon the type of flatfoot, the symptoms, and the stage of the disorder.
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Relapsing PolychondritisRelapsing polychondritis is an uncommon, chronic disorder of the cartilage that is characterized by recurrent episodes of inflammation of the cartilage of various tissues of the body. Tissues containing cartilage that can become inflamed include the ears, nose, joints, spine, and windpipe (trachea). Tissues that have a biochemical makeup similar to that of cartilage such as the eyes, heart, and blood vessels, can also be affected.
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Juvenile Rheumatoid Arthritis (JRA)Juvenile rheumatoid arthritis (JRA) affects one child in every thousand annually. There are six types of juvenile rheumatoid arthritis. Treatment of rheumatoid arthritis depends upon the type the child has and should focus on treating the symptoms.
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Is There a Cure for Cirrhosis of the Liver?Liver cirrhosis results from disease- or chemical-induced injury to the liver over a sustained period. The injury kills liver cells, and your body attempts to rebuild the damage. In the process, the existing cells are inflamed and scar tissue results, compromising the structure of the liver and hampering its function.
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Diffuse Idiopathic Skeletal Hyperostosis (DISH)Diffuse idiopathic skeletal hyperostosis (DISH or Forestier's disease) is a form of degenerative arthritis. It is characterized by calcification along the sides of the vertebrae of the spine. Symptoms include stiffness and pain in the upper and lower back. Anti-inflammatory medications are treatment.
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Rheumatoid Arthritis vs. FibromyalgiaThough rheumatoid arthritis (RA) and fibromyalgia have similar symptoms, RA is an autoimmune disease and fibromyalgia is a chronic pain syndrome. RA symptoms include joint redness, swelling, and pain that lasts more than 6 weeks. Fibromyalgia symptoms include widespread pain, tingling feet or hands, depression, and bowel irritability. Home remedies for both include stress reduction, exercise, and getting enough sleep.
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Is Crohn's Disease Related to Rheumatoid Arthritis?Since Crohn’s disease causes inflammation of the body, including the joints, sufferers are at a greater risk of developing rheumatoid arthritis.
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How Do I Know If It's Carpal Tunnel or Arthritis?Carpal tunnel syndrome and arthritis have different etiologies; thus, they manifest differently in the hand. Your doctor may subject you to physical examination, radiological tests, and neurological evaluation to diagnose.
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Eosinophilic Fasciitis (Shulman's Syndrome)Eosinophilic fasciitis (EF) is a rare disease that leads to inflammation and thickening of the skin and fascia underneath. In patients with eosinophilic fasciitis, the involved fascia is inflamed with the eosinophil type of white blood cells. This leads to symptoms of progressive thickening and often redness, warmth, and hardness of the skin surface.
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Menstrual Cramps and PMS (Premenstrual Syndrome) TreatmentLearn about the difference between menstrual cramps and PMS symptoms. Read about menstrual cramps and PMS (premenstrual syndrome) over-the-counter and prescription medications to relieve menstrual cramps and PMS symptoms.
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Can Fall Allergies Cause Sinus Headaches?Fall allergies can cause symptoms such as sneezing, congestion, and sinus headache. Learn more about causes, treatment, and prevention of fall allergies.
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Osteoarthritis vs. Rheumatoid ArthritisOsteoarthritis (OA) and rheumatoid arthritis (RA) are chronic joint disorders. RA is also an autoimmune disease. OA and RA symptoms and signs include joint pain, warmth, and tenderness. Over-the-counter pain relievers treat both diseases. There are several prescription medications that treat RA.
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Osgood-Schlatter DiseaseOsgood-Schlatter disease, a painful inflammation just below the knee but above the shin, typically affects adolescent boys. Symptoms include localized pain, inflammation, swelling, and calcification. Osgood-Schlatter disease typically goes away over time, however, symptoms can be helped with anti-inflammatory and pain-relieving medications, ice, and rest.
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Shoulder Impingement SyndromeShoulder impingement syndrome occurs due to repeated overhead activities and causes pain and discomfort in the shoulder. Check out the center below for more medical references on chronic pain, including multimedia (slideshows, images, and quizzes), related disease conditions, treatment and diagnosis, medications, and prevention or wellness.
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How Long Does Headache Last With COVID-19?Headache is a potential symptom of COVID-19 and can also occur after getting vaccinated. COVID-19 headaches typically last for a few days, although the duration depends on your age, immune system, and overall health condition. In mild cases of COVID-19, headaches will usually resolve within a few days. However, in more severe cases, mild or moderate headaches may come and go for up to 90 days.
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What Does a COVID-19 Headache Feel Like?COVID-19 headache may feel like a pulsing, pressing, or stabbing pain.
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Non-Radiographic Axial SpondyloarthritisNon-radiographic spondyloarthritis (nr-axSpA) is inflammatory arthritis that mainly affects the joints of the spine. Morning stiffness and back pain are the usual symptoms of non-radiographic spondyloarthritis (nr-axSpA).
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Quackery of ArthritisArthritis patients are sometimes vulnerable to quackery (the business of promoting unproven remedies). These "quick fix" treatments are promoted as cure-alls, but they really have no right to such claims. Consumers should be wary of products that have marketing claims like "will cure," "ancient remedy," "has no side effects," and "revolutionary new scientific breakthrough." Read about arthritis remedies and tests that have no scientific proof of benefits.
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Pain Management: Neuropathic PainNeuropathic pain is chronic pain resulting from injury to the nervous system. The injury can be to the central nervous system (brain and spinal cord) or the peripheral nervous system (nerves outside the brain and spinal cord).
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14 Early Signs of Arthritis in the LegsLeg arthritis affects the joints of the hips, knees, ankles or feet. The early signs and symptoms of arthritis in the legs include pain, swelling, stiffness, decreased range of motion, trouble walking, fever, bump-like swelling, and other symptoms.
Treatment & Diagnosis
- 5 Surprising Facts About Rheumatoid Arthritis
- Alzheimer's Disease - NSAID Protection?
- Celebrex - New Arthritis Drug
- Pain Management Over-The-Counter
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Medication Disposal
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Do NSAIDs Interact With Coumadin?
- Can You Have Ankylosing Spondylits Without the HLA-B27 Gene?
- What Are the Side Effects of Prednisone for Ankylosing Spondylitis?
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
- NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAID)-ORAL
- Drugs: Questions to Ask Your Doctor or Pharmacist about Your Drugs
- Drug Interactions
- ibuprofen
- diclofenac
- celecoxib (Celebrex)
- meloxicam
- Ibuprofen and Plavix
- ketorolac
- aspirin
- piroxicam, Feldene
- phenylbutazone (Butazolidine)
- naproxen
- OTC Pain Relievers and Fever Reducers
- Tramadol (Ultram) Side Effects
- Cox-2 Inhibitors
- indomethacin, Indocin, Indocin-SR (Discontinued Brand in U.S.)
- choline magnesium salicylate, Trilisate
- ketoprofen
- flurbiprofen (Ansaid)
- etodolac, Lodine (Discontinued)
- meclofenamate (Meclomen)
- Aspirin Therapy (Guidelines for Heart Attack and Stroke Prevention)
- salsalate, Amigesic, Salflex, Argesic-SA, Marthritic, Salsitab, Artha-G
- tolmetin (Tolectin [Discontinued Brand])
- ibuprofen (NSAID)
- Types of Migraine Headache Medications
- sulindac (Clinoril)
- diflunisal (Dolobid)
- nabumetone
- oxaprozin (Daypro)
- erenumab (Aimovig)
- Pennsaid (diclofenac sodium)
- Licart (diclofenac epolamine)
- Sprix (ketorolac tromethamine)
- valdecoxib, Bextra
- Side Effects of Ansaid (flurbiprofen)
- fenoprofen (Nalfon)
Prevention & Wellness
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
