- What is pseudoephedrine, and how does it work (mechanism of action)?
- What are the uses for pseudoephedrine?
- What are the side effects of pseudoephedrine?
- What is the dosage for pseudoephedrine?
- Which drugs or supplements interact with pseudoephedrine?
- Is pseudoephedrine safe to take if I'm pregnant or breastfeeding?
- What else should I know about pseudoephedrine?
What is pseudoephedrine, and how does it work (mechanism of action)?
- Pseudoephedrine is a decongestant used for reducing nasal congestion caused by allergies or the common cold. Pseudoephedrine causes blood vessels in the nasal passages to shrink (vasoconstrict). Vasoconstriction reduces nasal congestion by preventing fluid from draining from blood vessels into nasal passages. Pseudoephedrine also directly stimulates beta-adrenergic receptors and causes relaxation of bronchioles, as well as increased heart rate and contractility.
- The FDA approved pseudoephedrine in August 1975.
What brand names are available for pseudoephedrine?
Sudafed, Nexafed, Zephrex-D
Is pseudoephedrine available as a generic drug?
Yes
Do I need a prescription for pseudoephedrine?
No
What are the uses for pseudoephedrine?
- Pseudoephedrine is used for treating nasal and sinus congestion caused by the common cold or allergies.
What are the side effects of pseudoephedrine?
Common side effects of pseudoephedrine include:
- Tremor
- Restlessness
- Insomnia
- Nausea
- Vomiting
- Nervousness
- Possible serious side effects of pseudoephedrine include:
- High blood pressure
- Heart attack
- Abnormal heartbeats
- Ischemic colitis
Pseudoephedrine should not be used by people with severe hypertension or coronary artery disease. It should be used with caution in people with mild to moderate hypertension, cardiac disease, hyperthyroidism, hyperglycemia, benign prostatic hyperplasia, diabetes mellitus, kidney problems, seizure disorder, and glaucoma.
QUESTION
Which illness is known as a viral upper respiratory tract infection? See AnswerWhat is the dosage for pseudoephedrine?
- The recommended dose is 60 mg every 4 to 6 hours when using immediate release tablets. When using extended release tablets the recommended dose is 120 mg every 12 hours or 240 mg every 24 hours.
Which drugs or supplements interact with pseudoephedrine?
- Pseudoephedrine should not be combined with monoamine oxidase inhibitors (MAOIs) because such combinations may cause an acute hypertensive episode. Examples of MAOIs include rasagiline (Azilect), selegiline (Eldepryl, Zelapar), isocarboxazid (Marplan), phenelzine (Nardil), and tranylcypromine (Parnate).
Is pseudoephedrine safe to take if I'm pregnant or breastfeeding?
- Use of pseudoephedrine by pregnant women has not been adequately evaluated.
- Pseudoephedrine is secreted in breast milk. However, it is considered safe to use while nursing.
What else should I know about pseudoephedrine?
What preparations of pseudoephedrine are available?
- Tablet (immediate-release): 30, 60 mg; Tablet (extended-release): 120, 240 mg
Health News
- 5,000+ Measles Cases Threaten Canada’s Elimination Status
- Home Exercises Ease Knee Arthritis Pain
- Puberty: The Signs, Stages & When to See a Doctor
- Medical Debt May Soon Return to Credit Reports
- Sitting For Long Periods? Sip Cocoa Or Munch Berries To Protect Heart Health, Experts Say
More Health News »
Summary
Pseudoephedrine Plus Oral (Afrinol, Novafed, Sudafed) is a medication used to treat relief of sinus, nose, and ear congestion caused by the common cold. Side effects, drug interactions, and patient information should be reviewed prior to taking any medication.
Multimedia: Slideshows, Images & Quizzes
-
Prescription Drug Abuse: Addiction, Health Risks, and TreatmentsLearn how prescription drug and over-the-counter (OTC) drug abuse can endanger your health. Get the latest information on...
-
Cold, Fever and Flu Symptoms in Children: Medications and Home RemediesHow long does a cold last? How long is a cold contagious? Colds and fevers are some of the most common ailments in children....
-
Common Cold Quiz: Test Your Medical IQTake this quiz to learn the truth behind the infectious, contagious, uncomfortable disease known as the common cold. Test your...
-
Cold & Flu Quiz: Influenza vs. Common ColdAches? Pain? Fever? This Cold & Flu Quiz tests your knowledge on the difference between coming down with the common cold and...
-
How to Get Rid of a Cold: Natural RemediesWhat home remedies work to get rid of a cold fast? Many claim cold symptoms and flu symptoms can be relieved with Echinacea,...
-
The Most Common Food Allergies for Kids and AdultsWhat common food allergens cause the most problems for adults and children? See this list of common food allergies and learn to...
-
Common Allergies: Symptoms and SignsWhat are allergies? Pollen, food, perfumes, and many more things can provoke allergy symptoms. Allergies are an overreaction of...
-
How to Prevent the Common ColdWhat home remedies work for the common cold? The common cold is arguably the most common human illness. Learn how long the common...
-
10 Signs Your Allergies Are Out of ControlLearn 10 signs your allergies are out of control. See these surprising allergy symptoms and find out how to get relief for...
-
Nasal Irrigation: Natural Relief for Cold & Allergy SymptomsClogged sinuses and congestion bothering you? Nasal irrigation can relieve sinus symptoms associated with colds and allergies....
-
Nasal Allergy Attack: Causes, Triggers, TreatmentsNasal allergies are a common problem that affects millions of people. An allergist can recommend the best allergy nasal sprays...
-
10 Worst Cities for Spring AllergiesSee pictures of the top 10 "spring allergy capitals", according to the Asthma and Allergy Foundation of America (AAFA). From...
-
Flu Shots: 10 Facts About Flu ShotsWhat are the side effects of a flu shot? Who should get vaccinated? Learn the benefits and risks of vaccination for seasonal...
-
Pictures of Allergy Relief Tips at Home: AC Filters, Electronic Air Cleaners, and MoreLearn how a combination of medication, preventing allergens, and allergy relief products can reduce allergy symptoms and help you...
-
Home Allergy Quiz: Is Your Home Allergy-Proof?Take this home allergy quiz and test your knowledge on allergens, dust mites, pollens and more to see how allergy-proof your home...
Related Disease Conditions
-
SinusitisSinus infection (sinusitis) is caused by allergies, infection, and chemicals or other irritants of sinuses. Signs and symptoms include headache, fever, and facial tenderness, pressure, or pain. Treatments of sinus infections are generally with antibiotics and at times, home remedies.
-
Upper Respiratory Infection (URI)An upper respiratory infection is a contagious infection of the structures of the upper respiratory tract, which includes the sinuses, nasal passages, pharynx, and larynx. Common causes of an upper respiratory infection include bacteria and viruses such as rhinoviruses, group A streptococci, influenza, respiratory syncytial, whooping cough, diphtheria, and Epstein-Barr. Examples of symptoms of upper respiratory infection include sneezing, sore throat, cough, fever, and nasal congestion. Treatment of upper respiratory infections are based upon the cause. Generally, viral infections are treated symptomatically with over-the-counter (OTC) medication and home remedies.
-
Common ColdThe common cold (viral upper respiratory tract infection) is a contagious illness that may be caused by various viruses. Symptoms include a stuffy nose, headache, cough, sore throat, and sometimes a fever.
-
How to Stop CoughingLearn how to stop coughing attacks without medicine at night and at other times naturally. Learn about 19 tips to stop nighttime and persistent cough. Causes of excessive coughing include prescription medications, allergies, cigarette smoke, heart disease, and infections. Home remedies include natural herbs and supplements like ginger, honey, turmeric, and mint.
-
AllergyAn allergy refers to a misguided reaction by our immune system in response to bodily contact with certain foreign substances. When these allergens come in contact with the body, it causes the immune system to develop an allergic reaction in people who are allergic to it. It is estimated that 50 million North Americans are affected by allergic conditions. The parts of the body that are prone to react to allergies include the eyes, nose, lungs, skin, and stomach. Common allergic disorders include hay fever, asthma, allergic eyes, allergic eczema, hives, and allergic shock.
-
Raynaud's PhenomenonRaynaud's phenomenon (disease) occurs due to spasms of blood vessels. Raynaud's phenomenon is a type of vascular disease characterized by color changes of the skin, most commonly after exposure to cold. The cause of Raynaud's phenomenon is unknown, although abnormal nerve control of blood-vessel diameter and nerve sensitivity to cold is suspected of being involved.
-
Chronic CoughChronic cough is a cough that does not go away and is generally a symptom of another disorder such as asthma, allergic rhinitis, sinus infection, cigarette smoking, GERD, postnasal drip, bronchitis, pneumonia, medications, and less frequently tumors or other lung disease. Chronic cough treatment is based on the cause, but may be soothed natural and home remedies.
-
Hay FeverHay fever (allergic rhinitis) is an irritation of the nose caused by pollen and is associated with the following allergic symptoms: nasal congestion, runny nose, sneezing, eye and nose itching, and tearing eyes. Avoidance of known allergens is the recommended treatment, but if this is not possible, antihistamines, decongestants, and nasal sprays may help alleviate symptoms.
-
Sinus HeadacheSinus headache is caused by a sinus infection or inflammation of the sinus cavities. Symptoms of a sinus headache include pain, runny or stuffy nose, and chronic cough. There are many causes of sinus headaches including sinusitis or sinus infection, allergies, smoke, infections, or colds. Treatment for sinus headaches depends on the cause. Some home remedies may relieve sinus headache pain symptoms.
Treatment & Diagnosis
Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.