- What is guaifenesin, phenylephrine, and how does it work (mechanism of action)?
- What brand names are available for guaifenesin, phenylephrine?
- Is guaifenesin, phenylephrine available as a generic drug?
- Do I need a prescription for guaifenesin, phenylephrine?
- What are the side effects of guaifenesin, phenylephrine?
- What is the dosage for guaifenesin, phenylephrine?
- Which drugs or supplements interact with guaifenesin, phenylephrine?
- Is guaifenesin, phenylephrine safe to take if I'm pregnant or breastfeeding?
- What else should I know about guaifenesin, phenylephrine?
What is guaifenesin, phenylephrine, and how does it work (mechanism of action)?
Guaifenesin/phenylephrine is a medication that contains two different drugs, an expectorant (guaifenesin) and a decongestant (phenylephrine). The expectorant effects of guaifenesin promote drainage of mucus from the lungs by thinning the mucus. It also lubricates the irritated respiratory tract. Phenylephrine relieves stuffy nose by constricting blood vessels in the nasal air passages. This reduces the flow of fluid out of the blood vessels and into the tissues of the air passages.
What brand names are available for guaifenesin, phenylephrine?
Sudafed PE Non-Drying Sinus Caplets, (Entex, discontinued)
What are the side effects of guaifenesin, phenylephrine?
Side effects of guaifenesin/phenylephrine and include stimulation of the nervous system leading to nervousness, restlessness, excitability, dizziness, headache, fear, anxiety, tremor, and even hallucinations and convulsions (seizures). Nausea, vomiting, and rash also occur.
What is the dosage for guaifenesin, phenylephrine?
Guaifenesin/phenylephrine may be taken with or without food. It must be used cautiously in patients with heart (coronary artery) disease and angina, and diabetes.
Which drugs or supplements interact with guaifenesin, phenylephrine?
Guaifenesin/phenylephrine should not be taken with MAO inhibitors drugs due to the increased risk of serious adverse effects
QUESTION
Which illness is known as a viral upper respiratory tract infection? See AnswerIs guaifenesin, phenylephrine safe to take if I'm pregnant or breastfeeding?
Phenylephrine can cause birth defects in some animal species. Additionally, there have been associations between first trimester exposure to these medications and malformations, primarily minor malformations. Although one analysis found a correlation between guaifenesin use in the first trimester of pregnancy and an increased risk of hernia, others found no increased risk of malformations. Thus, guaifenesin/phenylephrine should be used in pregnancy only if the physician feels that the potential benefits outweigh the potential risks.
Small amounts of phenylephrine is excreted in breast milk.
What else should I know about guaifenesin, phenylephrine?
What preparations of guaifenesin, phenylephrine are available?
Caplet: 5 mg/200 mg
How should I keep guaifenesin, phenylephrine stored?
Store at room temperature below 30 C (86 F).
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Summary
Guaifenesin and phenylephrine (Sudafed PE Non-Drying Sinus Caplets, (Entex, discontinued) is a drug is prescribed for the relief of sneezing, nasal congestion from the common cold, runny nose, sinusitis, sore throat, or bronchitis. Side effects, drug interactions, dosage, and pregnancy safety information should be reviewed prior to taking this medication.
Related Disease Conditions
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MucusMucus is a standard substance produced by lining tissues in the body. Excess mucus or yellow, green, brown, or bloody mucus may indicate a problem. Mucus production may increase when allergies, a cold, flu, cough, or sore throat occur. Antihistamines and cold and flu medications may help alleviate excess mucus. A neti pot may be used to decrease nasal congestion and clear mucus.
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SinusitisSinus infection (sinusitis) is caused by allergies, infection, and chemicals or other irritants of sinuses. Signs and symptoms include headache, fever, and facial tenderness, pressure, or pain. Treatments of sinus infections are generally with antibiotics and at times, home remedies.
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Sore ThroatSore throat (throat pain) usually is described as pain or discomfort in the throat area. A sore throat may be caused by bacterial infections, viral infections, toxins, irritants, trauma, or injury to the throat area. Common symptoms of a sore throat include a fever, cough, runny nose, hoarseness, earaches, sneezing, and body aches. Home remedies for a sore throat include warm soothing liquids and throat lozenges. OTC remedies for a sore throat include OTC pain relievers such as ibuprofen or acetaminophen. Antibiotics may be necessary for some cases of sore throat.
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PneumoniaPneumonia is inflammation of the lungs caused by fungi, bacteria, or viruses. Symptoms and signs include cough, fever, shortness of breath, and chills. Antibiotics treat pneumonia, and the choice of the antibiotic depends upon the cause of the infection.
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Common ColdThe common cold (viral upper respiratory tract infection) is a contagious illness that may be caused by various viruses. Symptoms include a stuffy nose, headache, cough, sore throat, and sometimes a fever.
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How to Stop CoughingLearn how to stop coughing attacks without medicine at night and at other times naturally. Learn about 19 tips to stop nighttime and persistent cough. Causes of excessive coughing include prescription medications, allergies, cigarette smoke, heart disease, and infections. Home remedies include natural herbs and supplements like ginger, honey, turmeric, and mint.
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Acute BronchitisBronchitis is inflammation of the airways in the lung. Acute bronchitis is short (10-20 days) in comparison with chronic bronchitis, which lasts for months to years. Causes of acute bronchitis include viruses and bacteria, which means it can be contagious. Acute bronchitis caused by environmental factors such as pollution or cigarette smoke is not contagious. Common symptoms of acute bronchitis include nasal congestion, cough, headache, sore throat, muscle aches, and fatigue. Acute bronchitis in children also may include runny nose, fever, and chest pain. Treatment for acute bronchitis includes OTC pain relievers, cough suppressants (although not recommended in children), and rest. Infrequently antibiotics may be prescribed to treat acute bronchitis.
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Chronic BronchitisChronic bronchitis is a cough that occurs daily with the production of sputum that lasts for at least 3 months, 2 years in a row. Causes of chronic bronchitis include cigarette smoking, inhaled irritants, and underlying disease processes (such as asthma, or congestive heart failure). Symptoms include cough, shortness of breath, and wheezing. Treatments include bronchodilators and steroids. Complications of chronic bronchitis include COPD and emphysema.
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Cold, Flu, Allergy TreatmentsBefore treating a cold, the flu, or allergies with over-the-counter (OTC) medications, it's important to know what's causing the symptoms, which symptoms one wishes to relieve, and the active ingredients in the OTC product. Taking products that only contain the medications needed for relieving your symptoms prevents ingestion of unnecessary medications and reduces the chances of side effects.
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Sinus Infection vs. AllergiesBoth sinus infections and allergies (allergic rhinitis) cause symptoms such as runny or stuffy nose and fatigue. Sinus infection (known as sinusitis) is inflammation of the sinuses, caused by infection from bacteria, viruses, and/or fungi (molds). Allergic rhinitis occurs when certain allergies cause nasal symptoms. When a person with allergies breathes in an allergen, such as pollen, dust, or animal dander, symptoms such as runny or stuffy nose, itching, sneezing, and fatigue occur.
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Can Hot Weather Cause Sinus Problems?Sinusitis is a condition where you experience irritation and swelling of your sinuses. Allergies and sinus problems are common during the warmer seasons.
Treatment & Diagnosis
Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Reference: FDA Prescribing Information