nabumetone

Nabumetone belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Other members of this class include ibuprofen (Motrin), indomethacin (Indocin), naproxen (Aleve) and several others. These drugs are used for the management of mild to moderate pain, fever, and inflammation. They work by reducing the levels of prostaglandins, chemicals produced by the body that are responsible for pain, fever and inflammation. NSAIDs block the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced. Since the response to different NSAIDs varies from patient to patient, it is not unusual for a doctor to try different NSAIDs for any given condition. The FDA approved nabumetone in December 1991.

GENERIC AVAILABLE: Yes

Yes

Most patients, benefit from nabumetone and other NSAIDs with few side effects. However, serious side effects can occur, and generally tend to be dose-related. Therefore, it is advisable to use the lowest effective dose to minimize side effects. The most common side effects of nabumetone involve the gastrointestinal system, and these include:

• abdominal pain,
• cramping,
• nausea,
• gastritis,
• serious gastrointestinal bleeding, and
• liver toxicity.

Sometimes ulceration and bleeding can occur without any abdominal pain. Black, tarry stools, weakness, and dizziness upon standing may be the only signs of internal bleeding. Some studies have shown that nabumetone may have a lower risk of gastrointestinal side effects than the other NSAID medications.

Other important side effects caused by nabumetone include:

• rash,
• kidney impairment, and
• ringing in the ears.

NSAIDs reduce the ability of blood to clot and therefore increase bleeding after an injury. Nabumetone should be avoided by patients with a history of exacerbation of asthma, hives, or other allergic reactions to aspirin or other NSAIDs. Rare but severe allergic reactions have been reported in such individuals. Fluid retention (edema), blood clots, heart attacks, hypertension and heart failure have also been associated with the use of NSAIDs.

May be taken with or without food. The recommended starting dose for osteoarthritis or rheumatoid arthritis is 1000 mg daily as a single dose. Some patients may respond better to 1500 or 2000 mg daily. Doses may also be divided and administered twice daily. The lowest effective dose should be used.

It is not known whether nabumetone is excreted in breast milk.

What preparations of nabumetone are available?

Tablets: 500 and 750 mg

How should I keep nabumetone stored?

Nabumetone should be stored at 20 C to 25 C (68 F to 77 F), in a sealed, light- and moisture-resistant container.