Brand Name: Benadryl, Sominex, Unisom, Nytol, and several others
Generic Name: diphenhydramine
Drug Class: Generation Antihistamines, Antihistamines, Alkylamine Derivatives, Dermatologics, Other, Antihistamine/Decongestant Combos
What is diphenhydramine (Benadryl), and what is it used for?
Diphenhydramine (Benadryl) is an antihistamine used for treating allergic reactions. Histamine is released by the body during several types of allergic reactions and—to a lesser extent—during some viral infections, such as the common cold.
When histamine binds to receptors on cells, it stimulates changes within the cells that lead to the release of chemicals that cause sneezing, itching, and increased mucus production. Antihistamines compete with histamine for cell receptors and bind to the receptors without stimulating the cells.
In addition, they prevent histamine from binding and stimulating the cells. Diphenhydramine also blocks the action of acetylcholine (anticholinergic effect) and is used as a sedative because it causes drowsiness.
What are the side effects of diphenhydramine (Benadryl)?
Benadryl (diphenhydramine) side effects include:
- sedation,
- tiredness,
- sleepiness,
- dizziness,
- constipation,
- disturbed coordination,
- drying and thickening of oral and other respiratory secretions, and
- urinary retention.
Diphenhydramine also may cause:
- low blood pressure,
- palpitations (abnormal heartbeats),
- increased heart rate,
- confusion,
- nervousness,
- irritability,
- blurred vision,
- double vision,
- painful urination or difficulty urinating,
- tremor,
- sweating,
- loss of appetite,
- erectile dysfunction, and
- nausea.
Diphenhydramine should be used with caution (if at all) in persons with narrow-angle glaucoma, prostatic hypertrophy (enlarged prostate gland), hyperthyroidism, cardiovascular disease, high blood pressure (hypertension), and asthma.
What is the dosage for diphenhydramine (Benadryl)?
Diphenhydramine doses vary depending on the formulation and have their maximal effect about one hour after it is taken.
- When used to treat insomnia, it is prescribed at bedtime. Individuals over the age of 60 years are especially sensitive to the sedating and anticholinergic effects of diphenhydramine, and the dose should be reduced.
- A common regimen for treating adult allergic reactions is 25-50 mg every 4-6 hours not to exceed 300 mg daily.
- Insomnia is treated with 50 mg taken 30 minutes before bedtime.
QUESTION
Allergies can best be described as: See AnswerWhat drugs interact with diphenhydramine?
Diphenhydramine adds to (exaggerates) the sedating effects of alcohol and other drugs than can cause sedation.
This includes the following drug classes:
Benzodiazepines for-anxiety
- diazepam (Valium),
- lorazepam (Ativan),
- clonazepam (Klonopin),
- alprazolam (Xanax),
Narcotic pain medications and their derivatives
- oxycodone and acetaminophen (Percocet),
- hydrocodone and acetaminophen (Vicodin),
- guaifenesin with hydromorphone (Dilaudid),
- codeine,
- propoxyphene (Darvon),
Tricyclic antidepressants
Certain antihypertensive medications
Diphenhydramine also can intensify the drying effects of other medications with anticholinergic properties (for example, dicyclomine [Bentyl] and bethanechol [Urecholine], probanthine).
Is diphenhydramine safe to take if I'm pregnant or breastfeeding?
- Diphenhydramine has not been adequately evaluated in pregnant women. It should be used only if the benefit outweighs the potential but unknown risks.
- Diphenhydramine is secreted in breast milk. Because of the risk of stimulation and seizures in infants, especially newborns and premature infants, antihistamines should not be used by nursing mothers.
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Summary
Diphenhydramine (Benadryl) is an OTC and prescription injection medication used to treat hay fever, hives, allergic conjunctivitis, motion sickness, and mild cases of Parkinsonism. Side effects, drug interactions, dosage, storage, and pregnancy safety information should be reviewed before taking this medication.
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What Foods Cause Oral Allergy Syndrome?Oral allergy syndrome, also called pollen food allergy syndrome or PFAS, is a type of food allergy caused by certain allergens found in both pollen and raw vegetables and fruits and some nuts. Foods that cause oral allergy syndrome include those in the birch, grass and ragweed families.
Treatment & Diagnosis
- Questions To Ask Your Doctor - Allergy
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Travel Medicine Kit
- Are Hives Always Caused by an Allergy?
- Medication Disposal
- Do Allergy Drugs Interact with Synthroid?
- Allergy to Stinging Insects Can Be Life Threatening
- OTC Cold and Cough Medications
- Bug Bite Treatment
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
- Drugs: Questions to Ask Your Doctor or Pharmacist about Your Drugs
- Drug Interactions
- Hypnotics (for Sleep) Medications
- hydroxyzine
- Antihistamines (Oral)
- chlorpheniramine/pseudoephedrine
- Anticholinergic and Antispasmodic Drugs
- diphenhydramine topical
- chlordiazepoxide hydrochloride and clidinium bromide (Librax)
- Nasal Allergy Medications
- acetaminophen/diphenhydramine/dextromethorphan
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.