Generic Name: cortisone
Drug Class: Corticosteroids, Systemic
What is cortisone, and what is it used for?
Cortisone is a synthetic corticosteroid prodrug that is converted into cortisol in the body. Cortisol is a natural steroid hormone produced in the cortex region of the adrenal glands, hence known as a corticosteroid.
Cortisone is an anti-inflammatory and immunosuppressive drug used to control or reduce inflammation caused by a wide variety of conditions. Cortisone is also used to treat chronic adrenal insufficiency and to supplement inadequate natural cortisol production.
Cortisone inhibits pro-inflammatory signals and promotes anti-inflammatory signals. Cortisone binds to glucocorticoid receptors, protein molecules on cell membranes and activates multiple processes that help reduce inflammation, including:
- Controls the rate of protein synthesis
- Inhibits release of proinflammatory substances
- Prevents migration and aggregation of polymorphonuclear leukocytes (PMN), types of white cells such as neutrophils, eosinophils and basophils that release inflammatory substances
- Reduces capillary permeability to prevent the leakage of inflammatory cells and proteins (cytokines) into the inflammation site
- Prevents migration of fibroblasts, cells that form extracellular matrix, the supportive structure of tissue, and prevents scar tissue formation
Cortisone is administered as oral tablets to treat both adult and pediatric patients with conditions that include the following:
- Severe allergic states: Bronchial asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, perennial or seasonal allergic rhinitis, and serum sickness
- Dermatologic diseases: Severe psoriasis, severe seborrheic dermatitis, bullous dermatitis herpetiformis, exfoliative dermatitis, mycosis fungoides, pemphigus, and severe erythema multiforme (Stevens-Johnson syndrome)
- Endocrine disorders: Primary or secondary adrenocortical insufficiency, congenital adrenal hyperplasia, hypercalcemia associated with cancer, and nonsuppurative thyroiditis
- Gastrointestinal conditions: Acute episodes of regional enteritis and ulcerative colitis
- Blood disorders: Acquired (autoimmune) hemolytic anemia, congenital (erythroid) hypoplastic anemia, red blood cell anemia (erythroblastopenia), immune thrombocytopenia and secondary thrombocytopenia in adults
- Cancers: Palliative management of leukemias and lymphomas in adults and acute leukemia of childhood
- Ophthalmic conditions: Severe, acute, and chronic allergies and inflammations involving the eye such as allergic conjunctivitis, allergic corneal marginal ulcers, anterior segment inflammation, chorioretinitis, diffuse posterior uveitis and choroiditis, keratitis, herpes zoster ophthalmicus, iritis and iridocyclitis, optic neuritis, and sympathetic ophthalmia
- Rheumatic disorders: As adjunctive therapy for short-term to tide over an acute episode in acute gouty arthritis, acute and subacute bursitis, acute nonspecific tenosynovitis, ankylosing spondylitis, epicondylitis, posttraumatic osteoarthritis, psoriatic arthritis, rheumatoid arthritis (RA), including juvenile RA, and synovitis of osteoarthritis; and as maintenance therapy or during an exacerbation in select case of acute rheumatic carditis, systemic dermatomyositis (polymyositis), and systemic lupus erythematosus
- Respiratory diseases: Aspiration pneumonitis, berylliosis, fulminating or disseminated pulmonary tuberculosis used concurrently with appropriate antituberculosis chemotherapy, Loeffler syndrome not manageable by other means, symptomatic sarcoidosis
- Kidney diseases: To promote urination and remission of protein in urine (proteinuria) associated with idiopathic nephrotic syndrome or lupus erythematosus
- Others: Tuberculous meningitis with subarachnoid block or impending block used concurrently with appropriate antituberculous chemotherapy, and trichinosis with neurologic or myocardial involvement
Warnings
- Do not prescribe to patients with hypersensitivity to any of the components in the cortisone formulation.
- Do not use cortisone in patients with systemic fungal infection.
- Cortisone is not intended for intravenous use.
- Use the lowest possible dose to control the condition, particularly in elderly patients, and when dosage can be reduced, reduce gradually.
- Corticosteroids can cause suppression of hypothalamic-pituitary-adrenal axis, and potential for adrenal insufficiency after discontinuation, lasting for months. Institute corticosteroid replacement therapy in situations of stress during that period.
- Discontinuation of cortisone can cause withdrawal symptoms including fever, myalgia, arthralgia, and malaise even in patients without adrenal insufficiency. Withdraw with gradual tapering of dose.
- Patients on corticosteroid therapy subjected to unusual stress may require increased dosage of rapid-acting corticosteroids before, during, and after the stressful situation.
- Prolonged use of corticosteroids suppresses the immune system and may increase the risk of secondary infection, activate latent infections, mask acute infection, prolong or exacerbate viral infections, or limit response to killed or inactivated vaccines. Patients should be advised to avoid exposure to chickenpox or measles.
- Patients receiving immunosuppressive doses of corticosteroids should not take live or live, attenuated vaccines.
- Do not use corticosteroids for cerebral malaria or viral hepatitis.
- Amebiasis should be ruled out in patients who have recently traveled to tropical climates or those who have unexplained diarrhea, before initiation of cortisone.
- Use of cortisone in active tuberculosis should be restricted to cases of fulminating or disseminated tuberculosis (TB) in which it is used in conjunction with an appropriate antituberculous regimen. Patients with latent TB should be closely monitored.
- Prolonged use of corticosteroid can lead to cataracts, glaucoma, ocular inflammation and secondary eye infections.
- Cortisone can elevate blood pressure, cause water and sodium retention and increase excretion of potassium and calcium. Patients may require dietary salt restriction and potassium and calcium supplementation.
- Use cortisone with caution in patients with heart failure and/or hypertension.
- Use with caution in patients who have had a recent myocardial infarction. Rupture of left ventricular wall has been reported with corticosteroid use.
- Use with caution in patients with diabetes, corticosteroids can cause hyperglycemia.
- Prolonged use of corticosteroids is associated with development of Kaposi sarcoma, consider discontinuing therapy.
- Corticosteroid use is associated with psychiatric disturbances and exacerbation of pre-existing psychiatric conditions.
- Corticosteroids may cause mood and behavioral disturbances, caution the patient, family and caregivers.
- Acute myopathy has been reported with high-dose corticosteroids given concomitantly with neuromuscular blocking agents or in patients with neuromuscular transmission disorders. it may involve ocular and/or respiratory muscles, monitor creatine kinase.
- Use with caution in myasthenia gravis, may exacerbate symptoms.
- High doses and/or long-term use of corticosteroids have been known to increase bone loss and osteoporotic fractures, use with caution in patients with osteoporosis.
- Use cortisone with caution in gastrointestinal disease because of perforation risk.
- Use with caution in patients with ocular herpes simplex because of possible corneal perforation.
- Use with caution in kidney or liver function impairment, may cause fluid retention.
- Use with caution in patients with a history of seizure disorder, seizures have been reported with adrenal crisis.
- Changes in thyroid status may necessitate dosage adjustments.
- Do not use in the management of head injury, increased mortality has been reported in patients receiving high-dose intravenous methylprednisolone to manage head injuries.
- Corticosteroids may slow down growth and development in pediatric patients, monitor growth regularly.
QUESTION
Allergies can best be described as: See AnswerWhat are the side effects of cortisone?
Common side effects of cortisone include:
- Nausea
- Indigestion
- Reduced intestinal carbohydrate absorption
- Intestinal perforation
- Increased appetite
- Weight gain
- Fluid retention
- Sodium retention
- Reduced serum potassium (hypokalemia)
- Increased alkalinity of body fluids due to hypokalemia (hypokalemic alkalosis)
- Negative nitrogen balance
- Male pattern growth in women (hirsutism)
- Menstrual disorders
- Heart failure in susceptible patients
- Heart muscle (myocardial) rupture after recent heart attack (myocardial infarction)
- Blood clot block in blood vessel (thromboembolism)
- Tiny spots on skin due to bleeding under the skin (petechiae)
- Hives (urticaria)
- Thinning (atrophy) of skin
- Bruising of skin (ecchymosis)
- Redness of skin (erythema)
- Allergic dermatitis
- Excessive sweating (diaphoresis)
- Hypersensitivity reactions
- Swelling under the skin and mucous membranes (angioedema)
- Impaired wound healing
- Bulging eyes (exophthalmos)
- Cataract
- Nosebleed (epistaxis)
- Headache
- Increased intracranial pressure
- Feeling unwell (malaise)
- Vertigo
- Seizure
- Psychosis
- Joint pain (arthralgia)
- Steroid-induced muscle disease (myopathy)
- Tendon rupture
- Asymmetric muscle wasting in lower limbs (amyotrophy)
- Long bone fracture
- Aseptic tissue death (necrosis) of femoral or humeral head
Less common side effects of cortisone include:
- High blood pressure (hypertension)
- Blood clot in vein (venous thrombosis)
- Rapid and irregular heart rate in the atria (atrial fibrillation)
- Abdominal distension
- Peptic ulcer
- Ulcerative inflammation of the esophagus (esophagitis)
- Inflammation of the pancreas (pancreatitis)
- Agitation
- Anxiety
- Distractibility
- Euphoria
- Fear
- Hypomania
- Irritability
- Mood swings
- Lethargy
- Pressured speech
- Restlessness
- Tearfulness
- Brittle bones (osteoporosis)
- Vertebral compression fractures
- Glaucoma, an eye condition with high intraocular pressure that damages the optic nerve
- High blood sugar levels (hyperglycemia)
- Prediabetes
- Onset or exacerbation of diabetes mellitus
- Adrenal suppression
- Development of Cushing syndrome and cushingoid features such as:
- Moon face
- Abnormal fat deposits
- Weight gain around the midsection and upper back
- Abnormally elevated blood fat levels (dyslipidemia)
- Redistribution of body fat
- Growth retardation in children
Call your doctor immediately if you experience any of the following symptoms or serious side effects while using this drug:
- Serious heart symptoms include fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness;
- Severe headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady;
- Severe nervous system reaction with very stiff muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, and feeling like you might pass out; or
- Serious eye symptoms include blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights.
This is not a complete list of all side effects or adverse reactions that may occur from the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may also report side effects or health problems to the FDA at 1-800-FDA-1088.
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What are the dosages of cortisone?
Tablets
- 5 mg
- 10 mg
- 25 mg
Adult:
Anti-inflammatory/Immunosuppressive
- 2.5 mg/kg/day orally divided every 8 hours or 25-300 mg/day orally each day or divided every 12 hours
- 1-5 mg/kg intramuscularly each day
Physiologic Replacement
- 0.5-0.75 mg/kg/day orally divided every 8 hours or 25-35 mg/day
- 0.25-0.35 mg/kg intramuscularly each day
Pediatric:
Anti-inflammatory/Immunosuppressive
- 2.5 mg-10 mg/kg/day orally or 20-300 mg/m2/day orally divided every 6-8 hours
Physiologic Replacement
- 0.5-0.75 mg/kg/day orally or 20-25 mg/sq.meter/day orally divided every 8 hours
Overdose
- There is insufficient data on acute cortisone overdose. Chronic high doses because of prolonged therapy can cause many conditions including hypertension, hyperlipidemia, hyperglycemia, osteoporosis, electrolyte disturbances, immune suppression, and susceptibility to infections.
- Cortisone overdose treatment includes adjusting the dosage or discontinuing cortisone, as well as initiating symptomatic and supportive treatment.
What drugs interact with cortisone?
Inform your doctor of all medications you are currently taking, who can advise you on any possible drug interactions. Never begin taking, suddenly discontinue, or change the dosage of any medication without your doctor’s recommendation.
- Severe interactions of cortisone include:
- Cortisone has serious interactions with at least 73 different drugs.
- Cortisone has moderate interactions with at least 232 different drugs.
- Cortisone has minor interactions with at least 121 different drugs.
The drug interactions listed above are not all of the possible interactions or adverse effects. For more information on drug interactions, visit the RxList Drug Interaction Checker.
It is important to always tell your doctor, pharmacist, or health care provider of all prescription and over-the-counter medications you use, as well as the dosage for each, and keep a list of the information. Check with your doctor or health care provider if you have any questions about the medication.
Pregnancy and breastfeeding
- There are no adequate and well-controlled studies of cortisone use in pregnant women. There is some suggestion (not fully substantiated) of slightly increased cleft palate risk if corticosteroids are used in pregnancy.
- Use cortisone during pregnancy only if the benefits to the mother outweigh potential fetal risks. Monitor infants born to mothers who have received substantial doses of cortisone during pregnancy for signs of hypoadrenalism.
- Cortisone is present in breast milk and may suppress growth, interfere with natural (endogenous) corticosteroid production, or cause other untoward effects in the breastfed infant. Breastfeeding should be avoided while on cortisone treatment.
What else should I know about cortisone?
- Take cortisone exactly as prescribed, do not take higher or more frequent doses.
- Do not take live or live, attenuated vaccines while receiving cortisone treatment.
- Corticosteroids can increase susceptibility to infections. Take precautions to avoid exposure to infections.
- Report to your physician if you develop infections or severe allergic reactions.
- Corticosteroids may cause mood and behavioral disturbances, notify your physician if you notice any unexplained mood or behavioral changes.
- Store safely out of reach of children.
- In case of overdose, contact your physician or Poison Control.
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Summary
Cortisone is a synthetic corticosteroid prodrug that is converted into cortisol in the body. Cortisone is an anti-inflammatory and immunosuppressive drug used to control or reduce inflammation caused by a wide variety of conditions such as severe allergies, psoriasis, seborrheic dermatitis, rheumatoid arthritis, and others. Cortisone is also used to treat chronic adrenal insufficiency and to supplement inadequate natural cortisol production. Common side effects of cortisone include nausea, indigestion, reduced intestinal carbohydrate absorption, intestinal perforation, increased appetite, weight gain, fluid retention, and others. Consult your doctor if pregnant or breastfeeding.
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Can Rheumatoid Arthritis Be Caused by Stress?Rheumatoid arthritis can be caused by and result in stress, as well as other conditions such as gastrointestinal problems (IBD).
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Atopic Dermatitis vs. PsoriasisPsoriasis and atopic dermatitis are common, long-term skin diseases. Both are noncontagious. Because both the rashes look somewhat similar, the diagnosis may be difficult at the first glance, and a biopsy of the skin remains the last resort. However, certain things that can help differentiate between the two before the doctor orders a biopsy.
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The Best Treatment for Stasis DermatitisThe most effective way to treat stasis dermatitis is by controlling the disease.
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What Nuts Are the Worst for Allergies?A nut allergy develops when the body's immune system becomes oversensitive to a particular protein in a nut. Nuts that are the worst for allergies include peanuts, walnuts, pecans, almonds, Brazil nuts and pine nuts.
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Rheumatoid Arthritis vs. Ankylosing SpondylitisLearn the differences between rheumatoid arthritis and ankylosing spondylitis below.
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How Do You Treat Perioral Dermatitis?Perioral dermatitis (POD) is a rash that involves the skin around the mouth. The rash of POD is bumpy and scaly in appearance. There may be itching and pain, along with the discharge of clear fluid from the rash.
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Rheumatoid Arthritis vs. Lupus: Differences and SimilaritiesRheumatoid arthritis (RA) and lupus are two varieties of autoimmune diseases that cause flare-ups. While RA attacks the immune system on the joints, lupus involves many other parts of the body besides the joints. Common RA symptoms involve warm, swollen, and painful joints; morning stiffness in the joints or stiffness after inactivity, joint deformity, fever, fatigue, etc. Lupus symptoms include Malar rash (butterfly-shaped rash involving the cheeks and bridge of the nose), fever, joint pain in the absence of joint deformity, etc.
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How Can You Live With Arthritis in Your Back?Arthritis in the back can be extremely painful and in some cases debilitating. However, effective ways to manage and live with the condition.
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Allergy Treatment Begins at HomeAvoiding allergy triggers at home is one of the best ways to prevent allergy symptoms. Controlling temperature, humidity, and ventilation are a few ways to allergy-proof the home. Cleaning, vacuuming, and using HEPA air filters also helps control allergies.
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Are Food Allergies Passed Down Genetically?A food allergy is a condition that causes your immune system to fight against a particular part of food — which is called an allergen. Food allergies can be hereditary — that is, parents can pass the likelihood of developing a food allergy to their children through genes that code for inherited traits.
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Breastfeeding With Rheumatoid ArthritisYou can breastfeed your baby even if you have rheumatoid arthritis (RA). However, you must always consult your doctor before you start the process.
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Sinus Infection vs. AllergiesBoth sinus infections and allergies (allergic rhinitis) cause symptoms such as runny or stuffy nose and fatigue. Sinus infection (known as sinusitis) is inflammation of the sinuses, caused by infection from bacteria, viruses, and/or fungi (molds). Allergic rhinitis occurs when certain allergies cause nasal symptoms. When a person with allergies breathes in an allergen, such as pollen, dust, or animal dander, symptoms such as runny or stuffy nose, itching, sneezing, and fatigue occur.
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Rheumatoid Arthritis vs. Polymyalgia RheumaticaPolymyalgia rheumatica and rheumatoid arthritis are two diseases that manifest in a similar manner.
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Is Neurodermatitis an Autoimmune Disease?Researchers have suggested that there may be a link between neurodermatitis and autoimmune diseases, but the exact cause of the condition is unknown.
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What Is the Fastest Way to Fix Seasonal Allergies?Seasonal allergies are common and tend to ramp up during the spring and summer. Learn about how to get rid of seasonal allergies fast with these 13 home remedies.
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Atopic Dermatitis vs. Contact DermatitisThe word dermatitis refers to inflammation (redness and swelling) of the skin. Dermatitis includes various skin conditions that cause irritation or rashes on the skin. It generally causes no serious harm to the body and does not mean that the affected person’s skin is infected or unhygienic.
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Insect Sting AllergiesThe majority of stinging insects in the United States are from bees, yellow jackets, hornets, wasps, and fire ants. The severity of reactions to stings varies greatly. Avoidance and prompt treatment are essential. In selected cases, allergy injection therapy is highly effective.
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Juvenile Rheumatoid Arthritis (JRA)Juvenile rheumatoid arthritis (JRA) affects one child in every thousand annually. There are six types of juvenile rheumatoid arthritis. Treatment of rheumatoid arthritis depends upon the type the child has and should focus on treating the symptoms.
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How Do You Get Rid of Neurodermatitis?Treatment of neurodermatitis generally aims to control severe itching, prevent scratching, and address underlying causes. Learn about how to get rid of neurodermatitis.
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Latex AllergyLatex allergy is a condition where the body reacts to latex, a natural product derived from the rubber tree. The reaction can either be delayed and cause a skin rash or immediate, which can lead to anaphylaxis. Avoiding latex is the most effective way to prevent an allergic reaction.
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Peanut AllergyPeanut allergies cause signs and symptoms that include hives, itching, redness, and a rash. Severe reactions may cause decreased blood pressure, lightheadedness, difficulty breathing, nausea, and behavioral changes. Someone with a peanut allergy should have an EpiPen with them at all times.
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Rheumatoid Arthritis vs. FibromyalgiaThough rheumatoid arthritis (RA) and fibromyalgia have similar symptoms, RA is an autoimmune disease and fibromyalgia is a chronic pain syndrome. RA symptoms include joint redness, swelling, and pain that lasts more than 6 weeks. Fibromyalgia symptoms include widespread pain, tingling feet or hands, depression, and bowel irritability. Home remedies for both include stress reduction, exercise, and getting enough sleep.
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Is Crohn's Disease Related to Rheumatoid Arthritis?Since Crohn’s disease causes inflammation of the body, including the joints, sufferers are at a greater risk of developing rheumatoid arthritis.
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What Causes Allergy Flare-ups?During certain seasons, allergies can make you miserable. Learn what causes allergy flare-ups during spring and summer.
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How Do I Know If It's Carpal Tunnel or Arthritis?Carpal tunnel syndrome and arthritis have different etiologies; thus, they manifest differently in the hand. Your doctor may subject you to physical examination, radiological tests, and neurological evaluation to diagnose.
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What Is the Most Common Tree Nut Allergy?The most common nut allergies are cashew, walnut, hazelnut and pistachio. In the U.S. the most common nut allergy is cashew, followed by walnut. In the U.K. the most common nut allergy is hazelnut.
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Why Won’t My Allergy Symptoms Go Away?Allergies happen when your body's immune system reacts to certain substances as though they are harmful. Allergy symptoms may not go away unless you avoid your triggers, stick to your medications, find the right combination of medications, and consider surgery.
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Can Fall Allergies Cause Sinus Headaches?Fall allergies can cause symptoms such as sneezing, congestion, and sinus headache. Learn more about causes, treatment, and prevention of fall allergies.
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Osteoarthritis vs. Rheumatoid ArthritisOsteoarthritis (OA) and rheumatoid arthritis (RA) are chronic joint disorders. RA is also an autoimmune disease. OA and RA symptoms and signs include joint pain, warmth, and tenderness. Over-the-counter pain relievers treat both diseases. There are several prescription medications that treat RA.
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Drug AllergyDrug or medication allergies are caused when the immune system mistakenly creates an immune response to a medication. Symptoms of a drug allergic reaction include hives, rash, itchy skin or eyes, dizziness, nausea, diarrhea, fainting, and anxiety. The most common drugs that people are allergic to include penicillins and penicillin type drugs, sulfa drugs, insulin, and iodine. Treatment may involve antihistamines or corticosteroids. An EpiPen may be used for life-threatening anaphylactic symptoms.
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COVID-19 vs. AllergiesThough there is some overlap in allergy and COVID-19 signs and symptoms there are also significant differences. Symptoms that they have in common include headache, fatigue, tiredness, shortness of breath, wheezing, and sore throat. Fever does not occur with allergies but is one of the defining symptoms of COVID-19 infections.
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How Can I Help My Child With a Peanut Allergy?Since there is no cure for peanut allergies, prevention and keeping an epinephrine injector (EpiPen) on hand is key to helping your child’s allergy.
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Non-Radiographic Axial SpondyloarthritisNon-radiographic spondyloarthritis (nr-axSpA) is inflammatory arthritis that mainly affects the joints of the spine. Morning stiffness and back pain are the usual symptoms of non-radiographic spondyloarthritis (nr-axSpA).
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What Foods Cause Oral Allergy Syndrome?Oral allergy syndrome, also called pollen food allergy syndrome or PFAS, is a type of food allergy caused by certain allergens found in both pollen and raw vegetables and fruits and some nuts. Foods that cause oral allergy syndrome include those in the birch, grass and ragweed families.
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What Are the Symptoms of Ragweed Allergy?The common symptoms of ragweed allergy are sneezing, runny nose, itchy, watery red eyes, headache, nasal congestion, eye swelling, rashes and coughing.
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Is Food Intolerance the Same as Food Allergy?Food intolerance is a condition in which an individual has difficulty in digesting certain foods. Consumption of these foods manifests as physical symptoms such as bloating, loose motion, gases, and bellyache. Food intolerance is quite common. Most people are aware of the foods that disagree with them.
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14 Early Signs of Arthritis in the LegsLeg arthritis affects the joints of the hips, knees, ankles or feet. The early signs and symptoms of arthritis in the legs include pain, swelling, stiffness, decreased range of motion, trouble walking, fever, bump-like swelling, and other symptoms.
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How Do You Get Tested for Food Allergies?If you develop symptoms of a food allergy, your doctor will have you undergo a skin test or blood test to determine which foods you are allergic to.
Treatment & Diagnosis
- Rheumatoid Arthritis (RA): 17 Warning Signs of Serious Complications
- Living With Rheumatoid Arthritis
- Is Inflammatory Arthritis the Same as Rheumatoid Arthritis?
- Rheumatoid Arthritis vs. Osteoarthritis
- Is HCQ Safe For Pregnant Women With Rheumatoid Arthritis (RA)?
- Are Corticosteroids Safe for Pregnant and Nursing Women with Rheumatoid Arthritis?
- Patient Story: Rheumatoid Arthritis Symptoms
- 5 Surprising Facts About Rheumatoid Arthritis
- Patient Story: Rheumatoid Arthritis and Pregnancy
- Sesame Seed Allergy: A Growing Problem?
- Are Hives Always Caused by an Allergy?
- Celebrex - New Arthritis Drug
- Arthritis - Whether Weather Affects Arthritis
- Arthritis Medications
- Questions To Ask Your Doctor - Allergy
- Do NSAIDs Interact With Coumadin?
- Can Milk Allergy Cause Rheumatoid Arthritis?
- Osteoarthritis of the Hands
- Does Lipitor Help Rheumatoid Arthritis?
- Do Allergy Drugs Interact with Synthroid?
- Is Skin Discoloration a Side Effect of Cortisone Injection?
- Allergy to Stinging Insects Can Be Life Threatening
- Osteoarthritis Symptoms
- Herniated Disc - Epidural Cortisone Injections
Medications & Supplements
From 
Allergies Resources
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
https://www.rxlist.com/consumer_cortisone_cortone/drugs-condition.htm
https://reference.medscape.com/drug/cortisone-342742
https://www.uptodate.com/contents/cortisone-acetate-drug-information
https://cortisone-info.com/en/general-information/what-is-cortisone/
https://go.drugbank.com/drugs/DB01380