What are oral antihistamines, and what are they used for?
The term, antihistamine generally is used for medications used to treat various symptoms believed to be caused by histamine, for example, as part of the common cold, including:
- Congestion
- Runny nose
- Sneezing
- Itchy throat
- Hives
- Skin rashes
- Itching
- Itchy or watery eyes
Antihistamines also may be used to treat motion sickness, insomnia (difficulty sleeping), and anxiety. Antihistamines work by blocking the effects of a chemical called histamine that is responsible for many allergic symptoms.
Patients who experience significant allergic symptoms regularly may take daily antihistamines to keep their symptoms under control. Antihistamines also can be used on an as-needed basis for those who experience occasional symptoms or symptoms triggered by exposure to certain irritants such as animal hair, plants, medications, and food products. Some antihistamines also may be used occasionally to help with sleep.
Many different brands and forms of oral antihistamines are available over the counter (OTC). Oral antihistamines are available as pills, chewable tablets, orally disintegrating tablets, capsules, and liquid. Some antihistamines are found in combination pills that contain other medications. For example, antihistamines are commonly combined with decongestants (for example, Claritin-D, Zyrtec-D, Allegra-D), a class of medicine that is used to dry up the nasal passages and relieve head congestion.
Antihistamines are divided into two categories, first-generation or older agents and second-generation or newer agents. First-generation antihistamines have many drawbacks including side effects of drowsiness and significant anticholinergic side effects that, for example, can cause difficulty urinating or constipation, and are therefore not used very often. The newer antihistamines (second generation) are less likely to cause these side effects.
Antihistamines also differ in how long they work. Long-acting antihistamines provide symptom relief for up to 8-12 hours, while shorter-acting agents last for up to 4 hours but begin working faster.
A second type of antihistamine is used primarily for suppressing acid production in the stomach and treating acid-related diseases such as ulcers of the stomach.
What are examples of oral antihistamines available in the U.S.?
First generation antihistamines include
- brompheniramine
- chlorpheniramine (Chlor-Trimeton)
- diphenhydramine (Benadryl)
- doxylamine (found in many OTC sleep aids including Unisom)
- carbinoxamine (Karbinal ER)
Second generation antihistamines include
- fexofenadine (Allegra)
- loratadine (Claritin)
- loratadine ODT (Alavert, Tavist ND)
- desloratadine (Clarinex)
- certirizine (Zyrtec)
QUESTION
Allergies can best be described as: See AnswerWhat are the side effects of oral antihistamines?
First generation antihistamines are used less often to treat allergies because they cause significant sedation. First generation antihistamines also should be used cautiously in older adults as they are more susceptible to their anticholingeric side effects including
- drowsiness,
- dry mouth,
- decreased tear production,
- urinary retention (trouble urinating),
- blurred vision,
- constipation, and
- agitation.
Due to their significant side effect profile, special precautions should be used in patients with:
- Seizures
- Glaucoma
- Problems passing urine or men with prostate problems
- Thyroid disorders
- High blood pressure
- Diabetes
Second generation antihistamines are less sedating than their first generation counterparts. Cetirizine can be sedating for some patients at normal recommended doses while sedation seems to only be a concern with loratadine at higher than normally recommended doses. Fexofenadine is the least sedating.
Side effects common to all antihistamines include:
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What drugs interact with oral antihistamines?
Antihistamines may cause drowsiness. Taking antihistamines with other medicines that also are sedating may cause profound drowsiness. Examples include:
- Sleeping pills
- Alcohol
- Seizure medications
- Some antidepressants (especially tricyclic antidepressants)
- Antipsychotics
- Muscle relaxants
- Prescription narcotic pain medications
- Other antihistamines
- MAOIs (monoamine oxidase inhibitors), a class of medications used to treat mood disorders, may prolong or intensify the anticholinergic side effects of antihistamines. Generally, first generation antihistamines should not be used within two weeks of using a MAOI.
What about taking oral antihistamines during pregnancy or while breastfeeding?
- Non-drug interventions should always be considered first in pregnant women suffering from symptoms of allergic rhinitis. Nondrug therapies include saline or salt-water nasal sprays, exercise, and nasal strips.
- If a daily antihistamine is needed during pregnancy, second generation agents are preferred because they are less sedating and have a better side effect profile (have fewer anticholingeric side effects). Loratadine and cetirizine are preferred second generation antihistamines for pregnant women because they have the most safety and efficacy data. Both agents are rated FDA category B, and are generally considered to be safe at recommended doses for the treatment of allergic rhinitis during pregnancy. Fexofenadine is less well-studied and is rated FDA pregnancy category C.
- First generation antihistamines are usually used on an as-needed basis or before bedtime to occasionally help with sleep. Chlorpheniramine is the preferred first generation antihistamine for people who are pregnant because it has been studied the most.
What formulations of oral antihistamines are available?
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Summary
Oral antihistamines are medications used to treat symptoms of congestion, runny nose, the common cold, sneezing, itchy throat, skin rashes, hives, itching, and watery or itchy eyes. Some antihistamines also are used to treat anxiety, insomnia, and motion sickness. Common side effects of first-generation antihistamines include drowsiness, dry mouth, decreased tear production, urinary retention (trouble urinating), blurred vision, constipation, and agitation.
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How Can I Help My Child With a Peanut Allergy?Since there is no cure for peanut allergies, prevention and keeping an epinephrine injector (EpiPen) on hand is key to helping your child’s allergy.
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What Foods Cause Oral Allergy Syndrome?Oral allergy syndrome, also called pollen food allergy syndrome or PFAS, is a type of food allergy caused by certain allergens found in both pollen and raw vegetables and fruits and some nuts. Foods that cause oral allergy syndrome include those in the birch, grass and ragweed families.
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What Are the Symptoms of Ragweed Allergy?The common symptoms of ragweed allergy are sneezing, runny nose, itchy, watery red eyes, headache, nasal congestion, eye swelling, rashes and coughing.
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Is Food Intolerance the Same as Food Allergy?Food intolerance is a condition in which an individual has difficulty in digesting certain foods. Consumption of these foods manifests as physical symptoms such as bloating, loose motion, gases, and bellyache. Food intolerance is quite common. Most people are aware of the foods that disagree with them.
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Is Allergic Conjunctivitis the Same as Conjunctivitis?Allergic conjunctivitis may occur along with sneezing, runny nose, or sinus headache. Many people also find that they are tired and feel agitated.
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How Do You Get Tested for Food Allergies?If you develop symptoms of a food allergy, your doctor will have you undergo a skin test or blood test to determine which foods you are allergic to.
Treatment & Diagnosis
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- Medication Disposal
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Medications & Supplements
- loratadine, Claritin, Claritin RediTabs, Alavert, Claritin Hives Relief, Children's Claritin
- hydroxyzine
- Antihistamine Shots (Injections)
- diphenhydramine
- Cold Medicine and Cough Syrup for Adults
- cetirizine (Zyrtec, Zyrtec Allergy, Zyrtec Hives)
- fexofenadine (Allegra, Mucinex Allergy)
- Nasal Decongestants
- loratadine and pseudoephedrine (Alavert Allergy & Sinus, Claritin-D, Claritin-D 24 hour)
- fexofenadine and pseudoephedrine (Allegra-D)
- decongestant/antihistamine/anticholinergic - oral
- Side Effects of Phenergan with Codeine (promethazine and codeine)
- dextromethorphan/decongestant/antihistamine - oral
- desloratadine (Clarinex, Clarinex Reditabs)
- narcotic antitussive/antihistamine - oral
- decongestant/narcotic antitussive/antihistamine - oral
- decongestant/narcotic antitussive/acetaminoph/antihistamine - oral
Prevention & Wellness
From 
Allergies Resources
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
U.S. Food and Drug Administration