Generic Name: dopamine
Brand Name: Intropin (discontinued)
Drug Class: Inotropic Agents, Antipsychotics, First Generation
What is dopamine injection, and what is it used for?
- Dopamine is prescribed to correct hemodynamic status in patients with shock syndrome due to
- heart attack (myocardial infarction),
- trauma,
- open-heart surgery,
- renal failure,
- congestive heart failure, and
- other causes of shock syndrome.
- This means dopamine may be capable of improving urine flow, blood pressure, blood flow to vital organs, and improving heart function in patients with shock syndrome.
What are the side effects of dopamine injection?
Common side effects of dopamine include
Serious side effects of dopamine include
- abnormal heart rhythm,
- increased or decreased blood pressure,
- increased pressure in the eye, and
- gangrene in the extremities.
What is the dosage for dopamine injection?
FOR ADULTS
Dopamine is given by intravenous (IV) infusion.
- Low dose: 1 to 5 mcg/kg/minute IV to increase urine output and kidney blood flow.
- Intermediate dose: 5 to 15 mcg/kg/minute IV to increase kidney blood flow, cardiac output and contractility, and heart rate.
- High dose: 20 to 50 mcg/kg/minute IV to increase blood pressure and stimulate vasoconstriction; may increase infusion by 1 to 4 mcg/kg/minute at 10 to 30 minute intervals until desired response (for example, adequate blood pressure) is achieved.
Safe and effective use of dopamine is not established in children.
Which drugs interact with dopamine injection?
- Dopamine should not be used in patients with pheochromocytoma and abnormal heart rate and rhythm.
- Dopamine should not be used with medications like selegiline (Eldepryl, Zelapar), linezolid (Zyvox), and MAIO inhibitors like phenelzine (Nardil), isocarboxazid (Marplan) due to increased risk of a hypertensive episode.
- Dopamine should not be used with tricyclic antidepressants (for example, amitriptyline [Elavil, Endep]) that increase dopamine and norepinephrine due to increased risk of hypertension and abnormal heart rate and rhythm.
QUESTION
In the U.S., 1 in every 4 deaths is caused by heart disease. See AnswerPregnancy and breastfeeding
- There are no adequate studies done on dopamine to determine its safe and effective use in pregnant women.
- It is not known whether dopamine enters breast milk; therefore, it is best to be cautious before using it in nursing mothers.
What else should I know about dopamine injection?
What preparations of dopamine-injection are available?
- Additive solutions for IV infusion: 40, 80, 160 mg/ml.
- Infusion Solution: 80, 160, 320, mg/100 ml
How should I keep dopamine-injection stored?
- Dopamine injections are stored at room temperature between 20 C to 25 C (68 F to 77 F).
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Summary
Dopamine hydrochloride is a prescription injection medication prescribed to correct hemodynamic status in people with shock syndrome due to trauma, open-heart surgery, kidney failure, congestive heart failure, and other causes of shock syndrome. Common side effects of dopamine include disordered breathing, nausea, vomiting, headache, and increased blood urea nitrogen. Serious side effects of dopamine include abnormal heart rhythm, increased or decreased blood pressure, increased pressure in the eye, and gangrene in the extremities.
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
REFERENCES:
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