dopamine

Generic Name: dopamine

Brand Name: Intropin (discontinued)

Drug Class: Inotropic Agents, Antipsychotics, First Generation

What is dopamine injection, and what is it used for?

What are the side effects of dopamine injection?

Common side effects of dopamine include

Serious side effects of dopamine include

  • abnormal heart rhythm,
  • increased or decreased blood pressure,
  • increased pressure in the eye, and
  • gangrene in the extremities.

What is the dosage for dopamine injection?

FOR ADULTS

Dopamine is given by intravenous (IV) infusion.

  • Low dose: 1 to 5 mcg/kg/minute IV to increase urine output and kidney blood flow.
  • Intermediate dose: 5 to 15 mcg/kg/minute IV to increase kidney blood flow, cardiac output and contractility, and heart rate.
  • High dose: 20 to 50 mcg/kg/minute IV to increase blood pressure and stimulate vasoconstriction; may increase infusion by 1 to 4 mcg/kg/minute at 10 to 30 minute intervals until desired response (for example, adequate blood pressure) is achieved.

Safe and effective use of dopamine is not established in children.

Which drugs interact with dopamine injection?

  • Dopamine should not be used in patients with pheochromocytoma and abnormal heart rate and rhythm.
  • Dopamine should not be used with medications like selegiline (Eldepryl, Zelapar), linezolid (Zyvox), and MAIO inhibitors like phenelzine (Nardil), isocarboxazid (Marplan) due to increased risk of a hypertensive episode.
  • Dopamine should not be used with tricyclic antidepressants (for example, amitriptyline [Elavil, Endep]) that increase dopamine and norepinephrine due to increased risk of hypertension and abnormal heart rate and rhythm.

QUESTION

In the U.S., 1 in every 4 deaths is caused by heart disease. See Answer

Pregnancy and breastfeeding

  • There are no adequate studies done on dopamine to determine its safe and effective use in pregnant women.
  • It is not known whether dopamine enters breast milk; therefore, it is best to be cautious before using it in nursing mothers.

What else should I know about dopamine injection?

What preparations of dopamine-injection are available?
  • Additive solutions for IV infusion: 40, 80, 160 mg/ml.
  • Infusion Solution: 80, 160, 320, mg/100 ml
How should I keep dopamine-injection stored?
  • Dopamine injections are stored at room temperature between 20 C to 25 C (68 F to 77 F).

Summary

Dopamine hydrochloride is a prescription injection medication prescribed to correct hemodynamic status in people with shock syndrome due to trauma, open-heart surgery, kidney failure, congestive heart failure, and other causes of shock syndrome. Common side effects of dopamine include disordered breathing, nausea, vomiting, headache, and increased blood urea nitrogen. Serious side effects of dopamine include abnormal heart rhythm, increased or decreased blood pressure, increased pressure in the eye, and gangrene in the extremities.

Treatment & Diagnosis

Medications & Supplements

Prevention & Wellness

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References
Medically reviewed by John P. Cunha, DO, FACOEP; Board Certified Emergency Medicine

REFERENCES:

FDA Prescribing Information.